|
rs118049207
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification and interaction analyses showed that SND1 rs118049207</span> multiplicatively interacted with the sex and drinking status of the patients to enhance their colorectal cancer risk (P = 1.56×10-3 and 1.41×10-2, respectively).
|
31579913 |
2020 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the angiotensin-converting enzyme I/D and angiotensinogen M235T polymorphisms are unlikely to correlate with colorectal cancer.
|
31642377 |
2020 |
|
rs2070804
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated the association of HSPB1 genetic polymorphisms rs2070804 with tumor depth with colorectal cancer.
|
31364192 |
2020 |
|
rs2072580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of haplotypes reveals that rs2072580 of the <i>ISCU</i> and <i>SART3</i> genes can be also associated with CRC.
|
31797724 |
2020 |
|
rs2470151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that <i>RP11-108K3.2</i> rs2470151 had a significant association with the risk of colorectal cancer; this may help to predict the susceptibility of colorectal cancer in Chinese populations.
|
31789575 |
2020 |
|
rs2555639
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism rs2555639 in 15-PGDH and colorectal cancer metastasis.
|
31646799 |
2020 |
|
rs397514632
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One known pathogenic variant in POLD1 was detected (p.S478N), together with variants in 17 candidate genes not previously associated with CRC.
|
31555933 |
2020 |
|
rs4796672
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> We have identified three SNPs associated with CRC risk and demonstrated a gender specificity of rs590352 and rs4796672.
|
31797724 |
2020 |
|
rs590352
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> We have identified three SNPs associated with CRC risk and demonstrated a gender specificity of rs590352 and rs4796672.
|
31797724 |
2020 |
|
rs6022999
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results revealed that the rs4809960 and rs6022999 were strongly associated with the CRC risk</span>, especially with the colon cancer risk.
|
31740231 |
2020 |
|
rs6068816
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the analysis of haplotypes consisting of rs2585428(G > A), rs4809960(T > C), rs6022999(A > G) and rs6068816(C > T) indicated that haplotype ATGC significantly decreased the CRC risk, especially the colon cancer risk.
|
31740231 |
2020 |
|
rs67052019
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An indel variant, rs67052019 at 1p13.3, was found to be associated with CRC risk at P=3.9 x 10-8 in Asians (OR per allele deletion=1.13, 95%CI=1.08-1.18).
|
31826910 |
2020 |
|
rs7198799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Remarkably, CRISPR/Cas9-guided single-nucleotide editing demonstrated the direct effect of rs7198799 on ZFP90 expression and CRC cellular malignant phenotype.
|
31641208 |
2020 |
|
rs7960917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Materials & methods:</b> The rs8720 and rs7960917 in <i>KRAS</i> 3'UTR for colorectal carcinoma (CRC) risk and survival were investigated in a case-control study.
|
31729889 |
2020 |
|
rs8720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Materials & methods:</b> The rs8720 and rs7960917 in <i>KRAS</i> 3'UTR for colorectal carcinoma</span> (CRC) risk and survival were investigated in a case-control study.
|
31729889 |
2020 |
|
rs1048290
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KEAP1-NRF2 in</span>teraction analysis revealed that the rs6721961, rs35652124, rs1048290</span>, and rs11545829 conferred the susceptibility to CRC.
|
30825237 |
2019 |
|
rs1063169
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs7101 and rs1063169 polymorphisms in the noncoding region of FOS are associated with the risk of developing colorectal cancer and the progression of colorectal cancer, which may be because the mutation enhances the expression of c-Fos protein to promote the incidence and development of colorectal cancer.
|
31261535 |
2019 |
|
rs1064795841
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings may shed light on the mechanism of AR in CRC, namely, that the PT harbored the same mutations as the AR and the lesions in both cases harbored the KRAS G13D mutation.
|
30896620 |
2019 |
|
rs10817938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these six SNPs, <i>XPA</i> rs10817938 CT/ TT genotypes retained its significant association with longer overall survival (OS) (<i>P</i>=0.008) in CRC patients receiving oxaliplatin-based chemotherapy (n=580).
|
30643454 |
2019 |
|
rs10889677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our results demonstrate that rs10889677 polymorphism is significantly associated with CRC risk.
|
31546198 |
2019 |
|
rs11042170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that harboring SNP [rs4930101 (<i>P</i> = 0.009), rs2735970 (<i>P</i> = 0.003), and rs11042170 (<i>P</i> = 0.003)] or carrying more than one combined risk genotypes significantly increased the risk for CRC [<i>P</i> < 0.0001, adjusted OR (95% CI) 6.48 (2.97-14.15)].
|
31452627 |
2019 |
|
rs11545829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KEAP1-NRF2 interaction analysis revealed that the rs6721961, rs35652124, rs1048290, and rs11545829 conferred the susceptibility to CRC.
|
30825237 |
2019 |
|
rs11600655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, we showed that the rs11600655 CC, rs640908 CT and rs66475048 GA genotypes are independent risk factors for CRC in the Chinese population.
|
30343388 |
2019 |
|
rs11938795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic variants T in rs11938795 and G in rs6822844 were significantly associated with a higher risk of CRC.
|
31519598 |
2019 |
|
rs121913366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rare BRAF L597Q mutation may be associated with aggressive tumor behavior in CRC.
|
31704811 |
2019 |