rs10012
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotypes of rs1056827 and rs10012 or rs1056827 and rs1056836 revealed an association with colorectal cancer which was significantly stronger in the homozygous carriers.
|
20701755 |
2010 |
rs10012
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis indicates that CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly polymorphisms do not support an association with colorectal cancer, and further studies are needed to investigate the association.
|
25115775 |
2014 |
rs10036748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, SNPs in this study except rs7708392 and rs10036748 were found a modest connection with CRC risk.
|
28915643 |
2017 |
rs10046
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs including rs2069521 and rs10046 in genes of cytochrome P450 (CYP) superfamily were found significantly associated with CRC risk.
|
25109722 |
2014 |
rs10049390
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
rs10090154
|
|
|
0.030 |
GeneticVariation |
BEFREE |
None of the other three single nucleotide polymorphisms, two associated with prostate (rs10090154 and rs7000448) and one with both prostate and colorectal cancers (rs6583267), was associated with breast cancer risk in our study.
|
18349290 |
2008 |
rs10090154
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found an increased risk of CRC with rs6983267 but not with rs10090154.
|
19857256 |
2009 |
rs10090154
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two correlated SNPs--rs10090154 and rs4242382--in Region 1 of chromosome 8q24, a prostate cancer susceptibility region, demonstrated statistically significant associations with colorectal cancer risk.
|
23935004 |
2014 |
rs1011970
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
|
27197191 |
2016 |
rs10152518
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
rs10165970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkin's lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 (breast); CLOCK rs3749474 (breast) and rs11943456 (breast); RORA rs7164773 (breast and breast cancer postmenopausal), rs10519097 (breast); RORB rs7867494 (breast cancer postmenopausal), PER3 rs1012477 (breast cancer subgroups) and assessed the level of quality evidence to be intermediate.
|
28177907 |
2017 |
rs10203853
|
|
|
0.010 |
GeneticVariation |
BEFREE |
UGT1A haplotype analysis found that the T-G haplotype in UGT1A10 exon 1 (block 2: rs17864678, rs10929251) decreased cancer risk for the colon [proximal (OR = 0.28, 95% CI = 0.11–0.69) and for the distal colon (OR = 0.32, 95% CI = 0.12–0.91)], and that the C-T-G haplotype in the 3′ region flanking the UGT1A shared exons (block 11: rs7578153, rs10203853, rs6728940) increased CRC risk in males (OR = 2.56, 95% CI = 1.10–5.95).
|
24822274 |
2014 |
rs10204525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 14 SNPs, CCL2 rs4586 and PDCD1 rs10204525 were found to have an influence on the survival outcomes of the patients with resectable CRC.
|
27339628 |
2016 |
rs10211
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the Czech population, carriers of the ancestral alleles of AGT rs699 and CYP3A7 rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of ENPP1 rs1044498 had a decreased risk (OR 0.79; p≤0.05).
|
23036011 |
2012 |
rs1021737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In subsequent univariate analyses, participants with variant rs1021737 genotype had a decreased risk of KRAS-mutated CRC (OR per allele = 0.72, 95% CI = 0.50, 1.05), and an increased risk of BRAF-mutated CRC (OR per allele = 1.56, 95% CI = 1.07, 2.30), with weak evidence for heterogeneity (Pheterogeneity = 0.01).
|
29694444 |
2018 |
rs1023890
|
|
A |
0.700 |
GeneticVariation |
GWASDB |
A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis.
|
24978480 |
2014 |
rs1028166
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.
|
25192705 |
2014 |
rs1031245702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the association between diets high in red meat or poultry and CRC risk.
|
21037106 |
2010 |
rs10318
|
|
|
0.730 |
GeneticVariation |
BEFREE |
At 15q13.3, rs10318 was associated with CRC in both populations.
|
20659471 |
2010 |
rs10318
|
|
|
0.730 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrated that the rs4779584 and rs10318 polymorphism at 15q13.3 is a risk factor associated with increased CRC/CRA susceptibility, but these associations vary in different ethnic populations.
|
25475391 |
2015 |
rs10318
|
|
|
0.730 |
GeneticVariation |
BEFREE |
In two of the five genes originally associated with CRC, we found evidence for association in AAs including rs1862748 in CDH1 (OR(Add) = 0.82, P = 0.02) and in GREM1 the SNPs rs10318 (OR(Rec) = 60.1, P = 0.01), rs11632715 (OR(Rec) = 2.36; P = 0.004) and rs12902616 (OR(Rec) = 1.28, P = 0.005), the latter which is in linkage disequilibrium with the previously identified SNP rs4779584.
|
24753543 |
2014 |
rs10318
|
|
|
0.730 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
rs1035209
|
|
T |
0.810 |
GeneticVariation |
GWASDB |
We conducted replication of top ranked single nucleotide polymorphisms (SNPs) in additional series totalling 14 037 cases and 15 937 controls, identifying a new CRC risk locus at 10q24.2 [rs1035209; odds ratio (OR) = 1.13, P = 4.54 × 10(-11)].
|
24737748 |
2014 |
rs1035209
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We conducted replication of top ranked single nucleotide polymorphisms (SNPs) in additional series totalling 14 037 cases and 15 937 controls, identifying a new CRC risk locus at 10q24.2 [rs1035209; odds ratio (OR) = 1.13, P = 4.54 × 10(-11)].
|
24737748 |
2014 |
rs1035209
|
|
T |
0.810 |
GeneticVariation |
GWASCAT |
We conducted replication of top ranked single nucleotide polymorphisms (SNPs) in additional series totalling 14 037 cases and 15 937 controls, identifying a new CRC risk locus at 10q24.2 [rs1035209; odds ratio (OR) = 1.13, P = 4.54 × 10(-11)].
|
24737748 |
2014 |