|
rs16892766
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs16892766
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We studied the generalizability of the associations with 11 risk variants for CRC on 8q23 (rs16892766), 8q24 (rs6983267), 9p24 (rs719725), 10p14 (rs10795668), 11q23 (rs3802842), 14q22 (rs4444235), 15q13 (rs4779584), 16q22 (rs9929218), 18q21 (rs4939827), 19q13 (rs10411210), and 20p12 (rs961253) in a multiethnic sample of 2,472 CRC cases, 839 adenoma cases and 4,466 controls comprised of European American, African American, Native Hawaiian, Japanese American, and Latino men and women.
|
21071539 |
2011 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We identified associations at two of the six CRC susceptibility loci in MLH1 mutation carriers from the combined LS cohort: 11q23.1 (rs3802842, HR = 2.68, p ≤ 0.0001) increasing risk of CRC, and rs3802842 in a pair-wise combination with 8q23.3 (rs16892766) affecting age of diagnosis of CRC (log-rank test; p ≤ 0.0001).
|
22987364 |
2013 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We confirmed the association of CRC risk with four SNPs, with odds ratio (OR) higher than previously reported: rs16892766 on 8q23.3 (OR: 1.88, 95% confidence interval (CI): 1.30-2.72; P=0.0007); rs4779584 on 15q13.3 (OR: 1.42, CI: 1.11-1.83; P=0.0061) and rs4939827 and rs58920878/Novel 1 on 18q21.1 (OR: 1.49, CI: 1.13-1.98; P=0.007 and OR: 1.49, CI: 1.14-1.95; P=0.0035).
|
25873010 |
2016 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For rs16892766, possession of the C-allele was associated with an elevated risk of CRC in a dose-dependent fashion, with homozygosity for CC being associated with a 2.16-fold increased risk.
|
19010329 |
2009 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to test 11 loci, reported to be associated with an increased or decreased risk of colorectal cancer: 8q23.3 (rs16892766), 8q24.21 (rs6983267), 9p24 (rs719725), 10p14 (rs10795668), 11q23.1 (rs3802842), 14q22.2 (rs4444235), 15q13.3 (rs4779584), 16q22.1 (rs9929218), 18q21.1 (rs4939827), 19q13.1 (rs10411210) and 20p12.3 (rs961253), in a Swedish-based cohort.
|
20648012 |
2010 |
|
rs16892766
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H.
|
18372905 |
2008 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
An association between SNP rs3802842 on chromosome 11q23.1 and rs16892766 on chromosome 8q23.3 and the risk of developing CRC and age of diagnosis was found in MLH1 mutation carriers.
|
21097774 |
2011 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Collectively, our analysis further supports previous findings that the rs16892766</span> polymorphism is significantly associated with CRC susceptibility.
|
25609216 |
2015 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H.
|
18372905 |
2008 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings demonstrated that rs16892766-C allele might be risk-conferring factors for the development of CRC, but not for CRA.
|
25293934 |
2015 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Pooled sample-based GWAS: a cost-effective alternative for identifying colorectal and prostate cancer risk variants in the Polish population.
|
22532847 |
2012 |
|
rs16892766
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
26151821 |
2015 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to perform an association study between risk variants: rs10795668, rs16892766, rs3802842 and rs4939827 and CRC risk in Croatian population.
|
24066093 |
2013 |
|
rs16892766
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
|
rs16892766
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
rs16892766
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, the association of most CRC susceptibility loci identified in initial GWAS seems to be invariant to the other risk factors considered; however, our results suggest potential modification of the rs16892766 effect by vegetable consumption.
|
22367214 |
2012 |
|
rs16892766
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H.
|
18372905 |
2008 |
|
rs4444235
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings demonstrated that BMP4-rs4444235 is a risk factor associated with increased CRC and CRA susceptibility, but these associations vary in different ethnic populations.
|
25647270 |
2015 |
|
rs4444235
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)).
|
19011631 |
2008 |
|
rs4444235
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis provides a robust estimate of the positive association between the rs4444235 and CRC risk and further emphasizes the importance of the rs4444235 in CRC risk prediction.
|
24932582 |
2014 |