|
rs459552
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In a large Scottish case-control study, we investigated the effects of adenomatous polyposis coli (APC) Asp1822Val (rs459552) and APC Glu1317Gln substitutions on colorectal cancer (CRC) risk and whether these associations were influenced by lifestyle and dietary factors.
|
18375958 |
2008 |
|
rs459552
|
|
|
0.070 |
GeneticVariation |
BEFREE |
When independently assessed in 971 patients with colorectal cancer and 954 healthy control subjects, none of the identified missense APC alterations conferred a significantly increased risk for colorectal cancer, odds ratio (95 percent confidence intervals): S130G = 3.1 (0.29-32.25), E1317Q = 1.08 (0.59-2.74), G2502S = 1 (0.65-1.63), D1822V (heterozygous) = 0.79 (0.64-0.98), D1822V (homozygous) = 0.82 (0.63-1.27).
|
18612690 |
2008 |
|
rs150973053
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When independently assessed in 971 patients with colorectal cancer and 954 healthy control subjects, none of the identified missense APC alterations conferred a significantly increased risk for colorectal cancer, odds ratio (95 percent confidence intervals): S130G = 3.1 (0.29-32.25), E1317Q = 1.08 (0.59-2.74), G2502S = 1 (0.65-1.63), D1822V (heterozygous) = 0.79 (0.64-0.98), D1822V (homozygous) = 0.82 (0.63-1.27).
|
18612690 |
2008 |
|
rs2229995
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When independently assessed in 971 patients with colorectal cancer and 954 healthy control subjects, none of the identified missense APC alterations conferred a significantly increased risk for colorectal cancer, odds ratio (95 percent confidence intervals): S130G = 3.1 (0.29-32.25), E1317Q = 1.08 (0.59-2.74), G2502S = 1 (0.65-1.63), D1822V (heterozygous) = 0.79 (0.64-0.98), D1822V (homozygous) = 0.82 (0.63-1.27).
|
18612690 |
2008 |
|
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Furthermore, APC I1307K carriers had greater numbers of adenomas and colorectal cancers per patient than noncarriers.
|
17854661 |
2007 |
|
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The I1307K variant was found in 32 subjects with non-CRC (7.9%).
|
17920230 |
2007 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, APC I1307K carriers had greater numbers of adenomas and colorectal cancers per patient than noncarriers.
|
17854661 |
2007 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K variant was found in 32 subjects with non-CRC (7.9%).
|
17920230 |
2007 |
|
rs1801166
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The APC E1317Q and I1307K polymorphisms in non-colorectal cancers.
|
17920230 |
2007 |
|
rs459552
|
|
|
0.070 |
GeneticVariation |
BEFREE |
These results suggest a significant interaction between the D1822V polymorphism and the dietary intakes of cholesterol, calcium, and fiber for CRC risk.
|
17556698 |
2007 |
|
rs121913331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The nonsense mutation Arg1114X in APC gene was found in five of 43 CRC tumor tissues.
|
17653897 |
2007 |
|
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We could find no group of Ashkenazi Jews with colorectal cancer for whom screening for I130</span>7K would be clinically useful.
|
16875934 |
2006 |
|
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Here, we used this design to evaluate inherited susceptibility to prostate cancer associated with APC I1307K using data from the Molecular Epidemiology of Colorectal Cancer study.
|
16537703 |
2006 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we used this design to evaluate inherited susceptibility to prostate cancer associated with APC I1307K using data from the Molecular Epidemiology of Colorectal Cancer study.
|
16537703 |
2006 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We could find no group of Ashkenazi Jews with colorectal cancer for whom screening for I130</span>7K would be clinically useful.
|
16875934 |
2006 |
|
rs1801166
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Given the substantial size of our study and the consistency of our findings with the results of our meta-analyses, we conclude that it is unlikely that APC E1317Q is associated with a clinically meaningful risk of colorectal cancer.
|
17119068 |
2006 |
|
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
While the I1307K APC mutation clearly confers an increased lifetime risk for colorectal cancer, there is a paucity of data on the natural history of colonic neoplasia in symptomatic and asymptomatic mutation carriers.
|
15733272 |
2005 |
|
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This excess can partially be attributed to inherited factors that are over represented in this population, such as the APC variant I1307K, which is associated with a modest increase in colorectal cancer risk.
|
16195945 |
2005 |
|
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The I1307K mutation is associated with a moderate excess risk for CRC, but age of onset seems not to be earlier and this variant is not associated with a multiple colonic polyp phenotype.
|
15929773 |
2005 |
|
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was no significant difference noted between I1307K carriers and noncarriers with regard to the percentage of patients with first-degree relatives with colorectal carcinoma.
|
15959913 |
2005 |
|
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Together with former evidence of I1307K being a risk factor for colorectal cancer, these data suggest that colonoscopic surveillance for colorectal adenomas and cancer may be warranted in I1307K carriers, even in the absence of other identifiable risk factors.
|
16228836 |
2005 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
While the I1307K APC mutation clearly confers an increased lifetime risk for colorectal cancer, there is a paucity of data on the natural history of colonic neoplasia in symptomatic and asymptomatic mutation carriers.
|
15733272 |
2005 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant difference noted between I1307K carriers and noncarriers with regard to the percentage of patients with first-degree relatives with colorectal carcinoma.
|
15959913 |
2005 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This excess can partially be attributed to inherited factors that are over represented in this population, such as the APC variant I1307K, which is associated with a modest increase in colorectal cancer risk.
|
16195945 |
2005 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Together with former evidence of I1307K being a risk factor for colorectal cancer, these data suggest that colonoscopic surveillance for colorectal adenomas and cancer may be warranted in I1307K carriers, even in the absence of other identifiable risk factors.
|
16228836 |
2005 |