rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The reported association between the APC I1307K mutation and colon cancer risk was supported by a correlation in these data between personal or family history of CRC or polyps and a gene mutation.
|
10756345 |
2000 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The I1307K polymorphism in APC has been found to predispose to colorectal cancer in Ashkenazi Jews, and has recently been associated with an increased risk for breast cancer in the same population.
|
10555757 |
1999 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Furthermore, compared with noncarriers, APC I1307K carriers had increased numbers of adenomas and colorectal cancers per patient (P=.03), as well as a younger age at diagnosis.
|
9973276 |
1999 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our findings support the hypothesis that the I1307K mutation is unique to the Ashkenazi Jews, contributes to tumor predisposition in colorectal cancer, and is unrelated to mismatch repair deficiency.
|
9869603 |
1999 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
An adenomatous polyposis coli (APC) gene variant (I1307K allele), which was recently reported in 1 in 17 Ashkenazi Jewish persons, may double the risk for colorectal cancer in that population.
|
10343885 |
1999 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis.
|
9869602 |
1999 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our data show that the I1307K variant is rare in the Norwegian population and should not be viewed as a candidate for susceptibility testing for colorectal cancer.
|
9679946 |
1998 |
rs1801155
|
|
A |
0.800 |
SusceptibilityMutation |
CLINVAR |
The I1307K allele was found in 6.1% of unselected Ashkenazi Jews and higher proportions of Ashkenazim with family or personal histories of CRC (ref.2).
|
9731533 |
1998 |
rs1801155
|
|
A |
0.800 |
SusceptibilityMutation |
CLINVAR |
The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.
|
9724771 |
1998 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Among the 1087 first-degree relatives, there were 23 cases of colorectal cancer; 3 of 100 relatives of probands with the I1307K allele (3.0%) had a history of colorectal cancer versus 20 of 987 relatives of probands without the I1307K allele (2.1%; relative risk, 1.48; 95% confidence interval, 0.45-4.88; P = 0.462).
|
9679945 |
1998 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Interestingly, the I1307K APC polymorphism, associated with an increased risk of colorectal cancer, is also present in this family.
|
9831355 |
1998 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The I1307K allele was found in 6.1% of unselected Ashkenazi Jews and higher proportions of Ashkenazim with family or personal histories of CRC (ref.2).
|
9731533 |
1998 |
rs1801155
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds.
|
9407954 |
1997 |
rs1801155
|
|
A |
0.800 |
SusceptibilityMutation |
CLINVAR |
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
|
9288102 |
1997 |
rs62619935
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Sequence analysis revealed that a patient with a high level of ASE who did not have a family history of CRC carried a nonsense mutation in APC (p.Arg216X).
|
21995949 |
2012 |
rs62619935
|
|
T |
0.710 |
CausalMutation |
CLINVAR |
|
|
|
rs755229494
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
rs121913224
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs121913327
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs137854573
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs137854575
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1400295986
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs145945630
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1554085355
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs397515734
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|