rs909797662
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To accomplish this, we first carried out an in silico analysis of RNA-seq databases and found that the distribution of alternative splicing isoforms of genes RPL13, HSP90B1, ENO1, EPDR1 and ZNF518B was altered in human CRC cell lines carrying the G13D KRAS mutation when compared to cell lines carrying wild-type KRAS.
|
27805251 |
2016 |
rs909797662
|
|
|
0.040 |
GeneticVariation |
BEFREE |
However, among the various <i>KRAS</i> mutations, that which encodes the G13D mutant protein (KRAS<sup>G13D</sup>) behaves differently; for unknown reasons, KRAS<sup>G13D</sup> CRC patients benefit from the EGFR-blocking antibody cetuximab.
|
31551296 |
2019 |
rs2227983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genotypes with the variant allele of EGFR R521K SNP confer a risk reduction to develop CRC.
|
21896992 |
2011 |
rs2227983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Epidermal growth factor receptor R497K polymorphism is a favorable prognostic factor for patients with colorectal carcinoma.
|
17575224 |
2007 |
rs2227983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Patients carrying the AA genotype of EGFR rs2227983 had a significantly higher CRC risk than those carrying the G allele (HR=2.55, 95% CI=1.25-5.17).
|
30275229 |
2018 |
rs1057519860
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study indicated that EGFR and S492R EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibody CH12, which specifically recognizes an EGFR tumor-specific epitope, can bind efficiently to S492R EGFR.
|
30671888 |
2019 |
rs1057519860
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal carcinoma before exposure to EGFR monoclonal antibodies.
|
24025416 |
2013 |
rs121434569
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The US Food and Drug Administration approved a liquid biopsy test for EGFR-activating mutations in patients with non-small-cell lung cancer as a companion diagnostic for therapy selection. ctDNA also allows for the identification of mutations selected by treatment such as EGFR T790M in non-small-cell lung cancer. ctDNA can also detect mutations such as KRAS G12V in colorectal cancer and BRAF V600E/V600K in melanoma.
|
30883505 |
2019 |
rs121434569
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The US FDA approved a liquid biopsy test for EGFR activating mutations in patients with non-small cell lung cancer (NSCLC) as a companion diagnostic for therapy selection. ctDNA also allows for the identification of mutations selected by treatment such as EGFR T790M in NSCLC. ctDNA can also detect mutations such as KRAS G12V in colorectal cancer and BRAF V600E/V600K in melanoma.
|
30335711 |
2018 |
rs373129709
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We suggest that EGF A61G genotype has a functional influence on EGF gene expression in normal colon in CRC patients.
|
17851837 |
2007 |
rs373129709
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The findings of this pilot study suggest that the cyclin D1 A870G and the EGF A61G polymorphisms may be useful molecular markers for predicting clinical outcome in CRC patients treated with single-agent Cetuximab.
|
16788380 |
2006 |
rs1050171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A synonymous polymorphism (rs1050171, p.Q787Q) was shown to be associated with improved overall survival (OS) in colorectal cancer patients.
|
27750395 |
2017 |
rs1282801317
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, two novel non-hotspot <i>KRAS</i> mutations were functionally characterized <i>in vitro</i>: KRAS E31D was identified from a genetic screen of colorectal cancer specimens at the UP-National Institutes of Health.
|
31289513 |
2019 |
rs1383485737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NTRK gene mutations were identified in MSH2/MLH1-mutant CRC including NTRK1 I699V, NTRK2 P716S, and NTRK3 R745L.
|
28591715 |
2017 |
rs397517134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was found between the CCND1 A870G polymorphism and overall survival in our 39 CRC subjects.
|
16788380 |
2006 |
rs756703787
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants.
|
25714871 |
2015 |
rs774487133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected a GGT insertion between codons 12 and 13 (c.36_37insGGT;p.G12_G13insG) in a CRC patient.
|
24594115 |
2014 |