|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the subgroup analysis by cancer types, SMAD7 rs12953717 polymorphism was significantly associated with colorectal cancer.
|
23472153 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results show association of rs4939827 with colorectal cancer</span> risk in Croatian population.
|
24066093 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among those with CRC, the minor allele (G) in rs4939827 was significantly associated with poorer overall survival (hazards ratio, 1.20; 95% CI, 1.02-1.42).
|
23104301 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs11874392
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer.
|
23560096 |
2013 |
|
rs11874392
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Additionally, gene-smoking interactions for rs11874392, rs10988706 and rs6478972 were also found to enhance the risk of CRC at both stages, with P for multiplicative interaction equal to 1.162×10(-6), 8.574×10(-8) and 9.410×10(-8) in combined analyses, respectively.
|
23275154 |
2013 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
When stratifying for race, the data showed that the rs12953717</span> was associated with a significantly increased CRC risk under all genetic models in Caucasians.
|
23949881 |
2014 |
|
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNPs rs7229639 and rs4939827 explained approximately 1% of the familial relative risk of CRC</span> in East Asians.
|
24448986 |
2014 |
|
rs7229639
|
|
A |
0.820 |
GeneticVariation |
GWASCAT |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
rs7229639
|
|
A |
0.820 |
GeneticVariation |
GWASDB |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
rs7229639
|
|
|
0.820 |
GeneticVariation |
BEFREE |
SNPs rs</span>7229639 and rs4939827 explained approximately 1% of the familial relative risk of CRC in East Asians.
|
24448986 |
2014 |
|
rs7229639
|
|
A |
0.820 |
GeneticVariation |
GWASCAT |
SNPs rs7229639 and rs4939827 explained approximately 1% of the familial relative risk of CRC in East Asians.
|
24448986 |
2014 |
|
rs7229639
|
|
A |
0.820 |
GeneticVariation |
GWASDB |
SNPs rs7229639 and rs4939827 explained approximately 1% of the familial relative risk of CRC in East Asians.
|
24448986 |
2014 |
|
rs4464148
|
|
|
0.780 |
GeneticVariation |
BEFREE |
The CRC association with rs7229639 remained statistically significant after adjusting for rs4939827 as well as three additional CRC risk variants (rs58920878, rs12953717 and rs4464148) reported previously in this region.
|
24448986 |
2014 |
|
rs58920878
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The CRC association with rs7229639 remained statistically significant after adjusting for rs4939827 as well as three additional CRC risk variants (rs58920878, rs12953717 and rs4464148) reported previously in this region.
|
24448986 |
2014 |
|
rs2337107
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that there was no significant association between rs2337107 and the risk of colorectal cancer.
|
24969865 |
2014 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
On the other hand, rs12953717 T allele showed a statistically significant association with CRC risk (adjusted OR=1.339, 95% CI: 1.017-1.764, p=0.037).
|
25640388 |
2015 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For SMAD7 gene, rs4939827 and rs4464148 are risk factors for CRC among Caucasian whereas rs12953717 could elevate the susceptibility to CRC in both Caucasian and Asian.
|
26579801 |
2015 |
|
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
26151821 |
2015 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Furthermore, the A allele of rs7014346, the A allele of rs10505477, and the T allele of rs4939827 were significantly related with an elevated risk of CRC only among Caucasian.Our study suggested that for CASC8 gene, SNP of rs7837328 and rs6983267 are risk factors for CRC among both Caucasian and Asian whereas rs7014346 and rs10505477 are risky gene polymorphisms only among Caucasian.
|
26579801 |
2015 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Based on genome-wide association studies (GWAS) a linkage between several variants such as single nucleotide polymorphisms (SNPs) in intron 3 of SMAD7 (mothers against decapentaplegic homolog7) were, rs12953717, rs4464148 and rs4939827 has been noted for susceptibility to colorectal cancer (CRC).
|
25640388 |
2015 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the European CRC-susceptibility SNPs, rs4939827 in SMAD7 was associated with a significant decreased risk of Korean CRC (age-/gender-adjusted odds ratio [95% confidence interval]: additive model, 0.67 [95% CI, 0.47-0.95]; dominant model, 0.59 [95% CI, 0.39-0.91]). rs4779584 and rs10795668 were associated with CRC risk in females and males, respectively.
|
23875689 |
2015 |
|
rs4464148
|
|
|
0.780 |
GeneticVariation |
BEFREE |
For SMAD7 gene, rs4939827 and rs4464148 are risk factors for CRC among Caucasian whereas rs12953717 could elevate the susceptibility to CRC in both Caucasian and Asian.
|
26579801 |
2015 |