Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. 30429230

2019

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE Heterozygous variants of rs1799832 in NUDT1 (HR = 2.97, 95% CI = 1.51-5.83) and rs13181 in ERCC2 (HR = 2.69, 95% CI = 1.10-6.55) were significantly associated with an increased risk of CRC compared with wild-type homozygous CC and TT genotypes, respectively. 29664240

2018

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE Asp312Asn, Lys751Gln and promoter -114 of the XPD gene were not found to be adequate predictive markers for colorectal cancer risk in Taiwan. 27069143

2016

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE This is the first study on DNA repair genetic polymorphisms in West Algerian population, and it suggests that the XRCC3 Thr241Met and XPD Lys751Gln polymorphisms may not be associated with the CRC risk in this population. 24687779

2014

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE We found that: (i) XPC C/A (i11) heterozygous variant is associated with increased risk of CRC [OR is 2.07 (95% CI 1.1391, 3.7782) P=0.038], (ii) XPD A18911C (Lys751Gln) is associated with decreased risk of CRC [OR=0.4497, (95% CI 0.2215, 0.9131) P=0.031] for an individual with at least one A allele at this locus. 21559836

2012

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE Association between polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln genes and prognosis of colorectal cancer in a Chinese population. 23317245

2012

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE The aim of this study was to investigate the associations between the APE1 Asp148Glu, hOGG1 Ser326Cys, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His polymorphisms and CRC risk in Turkish population. 21561390

2011

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE NER ERCC1 rs11615C>T and ERCC2 rs13181T>G polymorphisms are useful prognostic factors in oxaliplatin-based treatment of gastric and colorectal cancer. 21278243

2011

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE The association of OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms and the susceptibility to colorectal carcinoma with or without oxidative stress were evaluated. 20649433

2010

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE Therefore, the Lys751Gln polymorphism of the XPD gene and the Ser326Cys polymorphism of the hOGG1 gene are not associated with colorectal cancer in a Polish population. 19561388

2009

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE Very low prevalence of XPD K751Q polymorphism and its association with XPD expression and outcomes of FOLFOX-4 treatment in Asian patients with colorectal carcinoma. 19432884

2009

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE We suggest that ERCC2 2251A>C alleles may be genetic predictors of early CRC relapse. 18267032

2008

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE The results showed no interaction between the XPD Lys751Gln, XPA A23G, and XPD Asp312Asn polymorphisms and the environmental factors for the development of colorectal cancer. 17363013

2007

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE This hospital-based case-control study examined whether polymorphic DNA repair genes: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, play a role in the susceptibility to colorectal cancer. 15914278

2005

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE This study was designed to examine the polymorphisms associated with three DNA repair genes, namely: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, and investigate their role as susceptibility markers for colorectal cancer. 15679883

2005