rs540635787
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs17879961
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In total, 26,336 cases and 44,219 controls from 18 case-control studies were used in this meta-analysis, and significant associations of the CHEK2 I157T variant with cancer susceptibility were found (OR, 1.39; 95% CI, 1.19-1.63; p<0.0001), breast cancer (OR=1.58, 95% CI=1.42-1.75, p<0.00001) and colorectal cancer (OR=1.67, 95% CI=1.24-2.26, p=0.0008).
|
23713947 |
2013 |
rs17879961
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Rare variants in CHEK2 (I157T and possibly del1100C) also appear to be associated with CRC risk.
|
22294770 |
2012 |
rs17879961
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.
|
22901170 |
2012 |
rs17879961
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our result demonstrate for the first time that CHEK2 1100delC, IVS2+1G>A and I157T mutations have not been agenetic susceptibility factor for CRC in the Turkish population.
|
22521562 |
2012 |
rs17879961
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We conclude that CHEK2 I157T is not relevant for CRC risk in Bulgaria, but studies on a larger scale might help evaluate its possible significance in respect to disease characteristics.
|
20658728 |
2010 |
rs17879961
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We conclude that the I157T variant of CHEK2 increases the risk of colorectal cancer among MMR-negative, HNPCC/HNPCC-related families in Poland.
|
19876921 |
2010 |
rs17879961
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We conclude that the I157T and other alterations in its proximity predispose to sporadic but not to familial CRC in the Czech population.
|
18996005 |
2009 |
rs17879961
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We conclude that the I157T mutation increases the risk of colorectal cancer in the population, but that truncating mutations may confer a lower risk or no increase in risk.
|
17106448 |
2007 |
rs17879961
|
|
|
0.090 |
GeneticVariation |
BEFREE |
CHEK2 I157T associates with an increased risk of CRC: the association was observed both among familial and sporadic CRC patients.
|
16816021 |
2006 |
rs2236142
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A hospital-based case-control study, including 1,121 cases and 1,056 controls was conducted to evaluate the association between eight selected single nucleotide polymorphisms (SNPs) (rs35514263 in <i>ATR</i>; rs492510, rs558351 in <i>CHKE1</i>; rs189037 in <i>ATM</i>; rs2236141, rs5762748, rs2236142 and rs9620817 in <i>CHEK2</i>) in ATR-CHEK1 and ATM-CHEK2 pathways and the risk of colorectal cancer in a Chinese population by using TaqMan method.
|
29928473 |
2018 |
rs5762748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A hospital-based case-control study, including 1,121 cases and 1,056 controls was conducted to evaluate the association between eight selected single nucleotide polymorphisms (SNPs) (rs35514263 in <i>ATR</i>; rs492510, rs558351 in <i>CHKE1</i>; rs189037 in <i>ATM</i>; rs2236141, rs5762748, rs2236142 and rs9620817 in <i>CHEK2</i>) in ATR-CHEK1 and ATM-CHEK2 pathways and the risk of colorectal cancer in a Chinese population by using TaqMan method.
|
29928473 |
2018 |
rs9620817
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A hospital-based case-control study, including 1,121 cases and 1,056 controls was conducted to evaluate the association between eight selected single nucleotide polymorphisms (SNPs) (rs35514263 in <i>ATR</i>; rs492510, rs558351 in <i>CHKE1</i>; rs189037 in <i>ATM</i>; rs2236141, rs5762748, rs2236142 and rs9620817 in <i>CHEK2</i>) in ATR-CHEK1 and ATM-CHEK2 pathways and the risk of colorectal cancer in a Chinese population by using TaqMan method.
|
29928473 |
2018 |