|
rs1056836
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The GSTA1 rs3957356 TT (HR = 5.36, 95% CI = 2.39-12.0) and CYP1B1 rs1056836 CC (HR = 7.24, 95% CI = 3.51-14.9) were significantly associated with CRC risk when compared to wild-type CC and GG genotypes, respectively.
|
28714190 |
2018 |
|
rs1056836
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The previous published data on the association between CYP1A2*F (rs762551), CYP1B1 Leu432Val (rs1056836), Asn453Ser (rs180040), and Arg48Gly (rs10012) polymorphisms and colorectal cancer risk remained controversial.
|
25115775 |
2014 |
|
rs1056836
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No association is found between the CYP1B1 Leu432Val polymorphism and risk of CRC among Caucasians.
|
22190224 |
2012 |
|
rs1056836
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Haplotypes of rs1056827 and rs10012 or rs1056827 and rs1056836 revealed an association with colorectal cancer which was significantly stronger in the homozygous carriers.
|
20701755 |
2010 |
|
rs1056836
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Through an association study based on 1,023 cases and 1,121 controls, we examined the influence on CRC risk of environmental factors coanalyzed with combinations of six single nucleotide polymorphisms located in cytochrome P450 genes (c.-163A>C and c.1548T>C in CYP1A2, g.-1293G>C and g.-1053C>T in CYP2E1, c.1294C>G in CYP1B1, and c.430C>T in CYP2C9).
|
17627011 |
2007 |
|
rs1056827
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, significant interactions were observed between NAT1 acetylation and CYP1B1 rs1056827 and meat consumption.Our results suggest that xenobiotic-metabolizing SNPs are not only associated with CRC risk in patients with Lynch syndrome in Taiwan but also interact with meat consumption to modify the disease risk.Environ.Mol.Mutagen.59:69-78, 2018.© 2017 Wiley Periodicals, Inc.
|
28714190 |
2018 |
|
rs10012
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis indicates that CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly polymorphisms do not support an association with colorectal cancer, and further studies are needed to investigate the association.
|
25115775 |
2014 |
|
rs1800440
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The previous published data on the association between CYP1A2*F (rs762551), CYP1B1 Leu432Val (rs1056836), Asn453Ser (rs180040), and Arg48Gly (rs10012) polymorphisms and colorectal cancer risk remained controversial.
|
25115775 |
2014 |
|
rs1800440
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was found between the CYP1B1 Asn453Ser polymorphism and risk of CRC among Caucasians.
|
22459615 |
2012 |
|
rs10012
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotypes of rs1056827 and rs10012 or rs1056827 and rs1056836 revealed an association with colorectal cancer which was significantly stronger in the homozygous carriers.
|
20701755 |
2010 |
|
rs1056827
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotypes of rs1056827 and rs10012 or rs1056827 and rs1056836 revealed an association with colorectal cancer which was significantly stronger in the homozygous carriers.
|
20701755 |
2010 |
|
rs760025060
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, the variant genotypes (GG and GA) of the 453 A/G were not associated with CRC risk when compared with the wild-type AA homozygote (GG vs AA, OR=0.94, 95% CI=0.77-1.14; GA vs AA, OR=0.99, 95% CI=0.87-1.12).
|
22459615 |
2012 |
|
rs162558
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a suggestion of increased risk, albeit insignificant after correction for multiple testing, of CRC for individuals homozygous for CYP1B1 rs162558 and heterozygous for CYP1A2 rs2069522 (odds ratio [OR] = 1.36, 95% confidence interval [CI]: 1.03-1.80 and OR = 1.34, 95% CI: 1.00-1.79 respectively).
|
17615053 |
2007 |