rs16906252
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We provide evidence that rs16906252C>T is associated with elevated risk for MGMT-methylated colorectal cancer, likely mediated by constitutive epigenetic repression of the T allele.
|
27267851 |
2016 |
rs12917
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that the PARP-1 rs1136410: T > C polymorphism is a susceptibility factor for GI cancers, but the variant allele of MGMT rs12917: C > T polymorphism appears to be a protective factor for colorectal cancer.
|
24203816 |
2014 |
rs12917
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the tumour sites subgroup analysis, only the protective effects of Leu84Phe polymorphism were found in colorectal cancer, under CT versus CC comparison.
|
19892775 |
2010 |
rs16906252
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We show that the T allele at SNP rs16906252 is a key determinant in the onset of MGMT methylation in colorectal cancer, whereas the association of methylation at MGMT and CDKN2A suggests that these loci may be targets of a common mechanism of epigenetic dysregulation.
|
19734844 |
2009 |
rs16906252
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A correlation between methylation and the T allele of the rs16906252 single nucleotide polymorphism (SNP) in colorectal carcinomas has previously been reported.
|
19789298 |
2009 |
rs12917
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results suggest that the common Leu84Phe and Ile143Val polymorphisms in MGMT influence risk of colorectal cancer in women possibly through modulating estrogen receptor-dependent transcriptional activation, which has previously been shown to occur in response to DNA alkylation damage.
|
16633920 |
2006 |
rs199734815
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Case-control data showed over-representation of c.346C > T (p.H116Y) in familial CRC compared to controls, but no overall association of MGMT mutations with CRC predisposition.
|
30677446 |
2019 |
rs1625649
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MGMT -535G>T polymorphism (rs1625649) was found to be correlated with PFS in patients with advanced colorectal cancer treated with oxaliplatin-based chemotherapy.
|
20091185 |
2010 |
rs2308318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there was a significant association between two polymorphisms in MGMT with sporadic colorectal cancer: Arg128Gln (OR, 5.53; 95% CI) and Gly160Arg (OR, 3.04; 95% CI).
|
20192566 |
2009 |
rs2308321
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the common Leu84Phe and Ile143Val polymorphisms in MGMT influence risk of colorectal cancer in women possibly through modulating estrogen receptor-dependent transcriptional activation, which has previously been shown to occur in response to DNA alkylation damage.
|
16633920 |
2006 |
rs773919809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the mechanism responsible for the link between the C677T polymorphism and microsatellite instability was not apparent, this finding may provide a clue towards a better understanding of the pathogenesis of microsatellite instability in human colorectal cancer.
|
16819711 |
2006 |