Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121909242
rs121909242
C 0.700 CausalMutation CLINVAR

dbSNP: rs121909243
rs121909243
T 0.700 CausalMutation CLINVAR

dbSNP: rs28936407
rs28936407
A 0.700 CausalMutation CLINVAR

dbSNP: rs587776687
rs587776687
C 0.700 CausalMutation CLINVAR

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Several studies evaluated the association between peroxisome proliferators-activated receptor gamma (PPARγ) Pro12Ala (rs1801282), and His477His (rs3856806) polymorphisms and the risk of colorectal cancer (CRC).However, the results were not stable. 29970681

2018

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE In conclusion, our study indicates that <i>PPARG</i> rs1801282 C>G polymorphism might decrease the risk of overall CRC. 29246001

2017

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE The current meta-analysis has established that ADH1B (rs1229984) and PPARG (rs1801282) are two risk variants of CRC. 24552298

2014

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE PPAR-gamma 34 C>G is associated with colon cancer risk, but not associated with CRC and rectal cancer risk. 20440859

2010

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE This meta-analysis suggests that the Ala allele of the PPARgamma P12A polymorphism might be a protective factor for colorectal cancer, but a risk factor for gastric cancer. 20596649

2010

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE PPAR-gamma 34 C>G is associated with colon cancer risk, but not associated with CRC and rectal cancer risk. 20440859

2010

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE This meta-analysis suggests that the Ala allele of the PPARgamma P12A polymorphism might be a protective factor for colorectal cancer, but a risk factor for gastric cancer. 20596649

2010

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 17763950

2008

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 17763950

2008

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 16393309

2006

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. 16489531

2006

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE With adjustment for CRC risk factors, subjects with one or two copies of the G allele of the PPARgamma2 Pro12Ala polymorphism showed a statistically significant reduction in risk compared to those with the CC genotype [odds ratio (OR)=0.53, 95% confidence interval (CI)=0.30-0.92]. 16513680

2006

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE We studied the association of SNPs in the IL-6 (-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G and K469E), and PPARgamma (Pro12Ala) genes and the risk of CRC. 16937502

2006

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. 16965392

2006

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 16393309

2006

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. 16489531

2006

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE With adjustment for CRC risk factors, subjects with one or two copies of the G allele of the PPARgamma2 Pro12Ala polymorphism showed a statistically significant reduction in risk compared to those with the CC genotype [odds ratio (OR)=0.53, 95% confidence interval (CI)=0.30-0.92]. 16513680

2006

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE We studied the association of SNPs in the IL-6 (-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G and K469E), and PPARgamma (Pro12Ala) genes and the risk of CRC. 16937502

2006

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. 16965392

2006

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE After adjustment for age, sex, smoking habit, family history and family income, an increased risk of CRC was observed for the C/T + T/T genotype compared to the C/C genotype of the C161T polymorphism (odds ratio = 1.61, 95% confidence interval: 1.10-2.36), whereas no significant association was found for Pro12Ala (odds ratio = 1.06, 95% confidence interval: 0.70-1.61). 16108832

2005

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE After adjustment for age, sex, smoking habit, family history and family income, an increased risk of CRC was observed for the C/T + T/T genotype compared to the C/C genotype of the C161T polymorphism (odds ratio = 1.61, 95% confidence interval: 1.10-2.36), whereas no significant association was found for Pro12Ala (odds ratio = 1.06, 95% confidence interval: 0.70-1.61). 16108832

2005