rs4986790
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate TLR2 (-196 to-174del), TLR4 (Asp299Gly and Thr399Ile) and TLR9 (T1237C and T1486C) gene polymorphisms at risk of colorectal cancer (CRC) development and progression.
|
29883450 |
2018 |
rs4986790
|
|
|
0.070 |
GeneticVariation |
BEFREE |
To evaluate the effect of promoter region polymorphisms of toll-like receptor (TLR)2-196 to -174del and TLR4-1607T/C (rs10759932) on mRNA and protein expression in tumor tissue and of TLR4+896A/G (rs4986790) on colorectal cancer (CRC) risk.
|
26167073 |
2015 |
rs4986790
|
|
|
0.070 |
GeneticVariation |
BEFREE |
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to explore the role of IL1B_1473G/C (rs1143623), SOD1_7958A/G (rs4998557), TLR4_1196C/T (rs4986791), IL10_1082A/G (rs1800896), IL17A_197G/A (rs2275913), and TLR4_896A/G (rs4986790) polymorphisms in the susceptibility to colorectal cancer (n = 244), gastric carcinoma (n = 72), and ovarian cancer (n = 85).
|
24446182 |
2014 |
rs4986790
|
|
|
0.070 |
GeneticVariation |
BEFREE |
However, we found no evidence to support a significant association between TLR4 D299G and T399I polymorphisms and colorectal cancer susceptibility.
|
23949880 |
2014 |
rs4986790
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our study suggests that variant TLR4 (Asp299Gly and Thr399Ile alleles) as well as TLR2 (Arg753Gln allele) are not associated with risk of colorectal cancer.
|
21625017 |
2011 |
rs4986790
|
|
|
0.070 |
GeneticVariation |
BEFREE |
These findings indicated that the polymorphism of CD14 but not TLR4 Asp299Gly mutation was associated with Chinese patients with colorectal cancer, and the CD14 gene may contribute to the predisposition to colorectal cancer.
|
16706818 |
2006 |
rs4986790
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The mutant allele Asp299Gly of TLR4 gene was slightly more frequent in colorectal cancer patients (p = 0.0269).
|
16879199 |
2006 |
rs4986791
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate TLR2 (-196 to-174del), TLR4 (Asp299Gly and Thr399Ile) and TLR9 (T1237C and T1486C) gene polymorphisms at risk of colorectal cancer (CRC) development and progression.
|
29883450 |
2018 |
rs4986791
|
|
|
0.040 |
GeneticVariation |
BEFREE |
However, we found no evidence to support a significant association between TLR4 D299G and T399I polymorphisms and colorectal cancer susceptibility.
|
23949880 |
2014 |
rs4986791
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to explore the role of IL1B_1473G/C (rs1143623), SOD1_7958A/G (rs4998557), TLR4_1196C/T (rs4986791), IL10_1082A/G (rs1800896), IL17A_197G/A (rs2275913), and TLR4_896A/G (rs4986790) polymorphisms in the susceptibility to colorectal cancer (n = 244), gastric carcinoma (n = 72), and ovarian cancer (n = 85).
|
24446182 |
2014 |
rs4986791
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our study suggests that variant TLR4 (Asp299Gly and Thr399Ile alleles) as well as TLR2 (Arg753Gln allele) are not associated with risk of colorectal cancer.
|
21625017 |
2011 |
rs10759932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate the effect of promoter region polymorphisms of toll-like receptor (TLR)2-196 to -174del and TLR4-1607T/C (rs10759932) on mRNA and protein expression in tumor tissue and of TLR4+896A/G (rs4986790) on colorectal cancer (CRC) risk.
|
26167073 |
2015 |
rs5030728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous carriage of the variant allele of the TLR4/rs5030728 polymorphism was associated with increased risk of CRC (incidence rate ratio (IRR) = 1.30; 95% confidence interval (CI): 1.05-1.60; P = 0.02 (gene-dose model); IRR = 1.24; 95%CI: 1.01-1.51; P = 0.04 (recessive model)).
|
25705893 |
2015 |
rs1420111973
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our meta-analysis results revealed that the TLR-4 399 C>T polymorphism might increase the risk of CRC (allele model: OR = 1.77, 95%CI = 1.32 ∼ 2.36, P<0.001; dominant model: OR = 1.83, 95%CI = 1.32 ∼ 2.52, P<0.001; respectively).
|
24705379 |
2014 |
rs1927911
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Synergistic interactions between TLR 4 rs1927911 CT/TT and higher pungent food intake as well as IL17 rs6973569 AG/AA genotypes and higher intake of sausage food (ORi=1.72, 95% CI 1.04-2.84 and ORi=3.38, 95% CI 1.28-8.91) on the risk of CRC were observed.
|
25216863 |
2014 |
rs11536891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two CRP haplotypes (global p = 0.04) and TLR4 tagSNPs (rs7873784, rs11536891), but not TLR4 haplotypes, were associated with colorectal cancer.
|
19760027 |
2009 |
rs7873784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two CRP haplotypes (global p = 0.04) and TLR4 tagSNPs (rs7873784, rs11536891), but not TLR4 haplotypes, were associated with colorectal cancer.
|
19760027 |
2009 |