Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28934576
rs28934576
0.740 GeneticVariation BEFREE Our findings indicate the R270H/R273H p53 mutant protein does not manifest definite GOF biological effects in mouse and human CRCs, suggesting possible GOF effects of mutant p53 in cancer phenotypes are likely allele-specific and/or context-dependent. 31148594

2019

dbSNP: rs28934576
rs28934576
0.740 GeneticVariation BEFREE We therefore investigated the anti-tumor properties of a gold(I) <i>N</i>-heterocyclic carbene (NHC) complex-termed MC3-in human colorectal cancer (CRC) cell lines encompassing three different p53 variations: HCT116 wild-type (WT), HCT116 p53<sup>-/-</sup>, and HT-29 (mutant; R273H). 31231607

2019

dbSNP: rs28934576
rs28934576
0.740 GeneticVariation BEFREE Finally, lnc273-31 and lnc273-34 were significantly highly expressed in CRC tissues with p53-R273H mutation compared to those with wildtype p53. 31455383

2019

dbSNP: rs28934576
rs28934576
0.740 GeneticVariation BEFREE The CRC colorectal cancer (CRC) cell lines HCT116 wild-type (wt), HCT116 p53-/-, and HT-29 (mutant; R273H) were employed, covering three different p53 variations. 28618116

2017

dbSNP: rs28934576
rs28934576
T 0.740 CausalMutation CLINVAR

dbSNP: rs11540652
rs11540652
0.710 GeneticVariation BEFREE We show that the most common mutp53 allele R248Q (p53<sup>Q</sup>) exerts gain of function (GOF) and creates tumor dependence in mouse CRC models. mutp53 protein binds Stat3 and enhances activating Stat3 phosphorylation by displacing the phosphatase SHP2. 30107178

2018

dbSNP: rs11540652
rs11540652
T 0.710 CausalMutation CLINVAR

dbSNP: rs1131691003
rs1131691003
A 0.700 CausalMutation CLINVAR

dbSNP: rs1131691042
rs1131691042
T 0.700 CausalMutation CLINVAR

dbSNP: rs121912651
rs121912651
C 0.700 GeneticVariation CLINVAR

dbSNP: rs28934578
rs28934578
T 0.700 CausalMutation CLINVAR

dbSNP: rs55832599
rs55832599
A 0.700 GeneticVariation CLINVAR

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE This study replicated an association of <i>CCAT2</i> rs6983267 with CRC and an interaction between <i>TP53</i> rs1042522 and NSAID in relation to CRC. 30841568

2019

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis. 29872345

2018

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men. 30316510

2018

dbSNP: rs1131691014
rs1131691014
0.100 GeneticVariation BEFREE Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis. 29872345

2018

dbSNP: rs1131691014
rs1131691014
0.100 GeneticVariation BEFREE Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men. 30316510

2018

dbSNP: rs878854066
rs878854066
0.100 GeneticVariation BEFREE Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis. 29872345

2018

dbSNP: rs878854066
rs878854066
0.100 GeneticVariation BEFREE Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men. 30316510

2018

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population. 27901479

2017

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population. 28554075

2017

dbSNP: rs1131691014
rs1131691014
0.100 GeneticVariation BEFREE We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population. 27901479

2017

dbSNP: rs1131691014
rs1131691014
0.100 GeneticVariation BEFREE In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population. 28554075

2017

dbSNP: rs878854066
rs878854066
0.100 GeneticVariation BEFREE We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population. 27901479

2017

dbSNP: rs878854066
rs878854066
0.100 GeneticVariation BEFREE In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population. 28554075

2017