|
rs2241766
|
|
|
0.090 |
GeneticVariation |
BEFREE |
ADIPOQ SNPs rs2241766 T/G and rs 1501299 G/T have a population-specific correlation with risk of CRC.
|
27704292 |
2017 |
|
rs2241766
|
|
|
0.090 |
GeneticVariation |
BEFREE |
After adjusting for factors such as colorectal cancer family history, body-mass index (BMI), daily sedentary time, weekly red meat intake frequency, as well regular tea drinking, conditional logistic regression analysis indicated that rs2241766 TG+GG carriers had a higher risk of colorectal cancer than TT carriers (OR=1.433, 95% CI: 1.014-1.985); rs1501299 GT+TT carriers had a lower risk of colorectal cancer than GG carriers (OR=0.723, 95% CI: 0.531-0.902).
|
25489716 |
2015 |
|
rs2241766
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Using rs2241766 as an instrument in Mendelian randomization analysis, an increment of 1 mg/L in circulating adiponectin was significantly associated with a 43-50% reduced risk for lung cancer, but with a 20-40% increased risk of colorectal cancer, respectively.
|
25273172 |
2015 |
|
rs2241766
|
|
|
0.090 |
GeneticVariation |
BEFREE |
ADIPOQ rs2241766, ADIPOQ rs1501299 and CAPN-10 rs3792267 are significantly associated with CRC risk and the combination of the three polymorphisms and red meat affect CRC risk.
|
26203767 |
2015 |
|
rs2241766
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Results of the current meta-analysis revealed that the rs2241766 T>G single-nucleotide polymorphisms (SNP) increase the risk of CRC; rs1501299 G>T under dominant model was associated with increased risk of CRC; and rs266729 C>G SNP under allele model conferred an increased risk of CRC.
|
26329379 |
2015 |
|
rs2241766
|
|
|
0.090 |
GeneticVariation |
BEFREE |
With a hospital-based case-control study of 341 cases and 727 controls, the associations between the common variants on ADIPOQ (rs266729, rs822395, rs2241766 and rs1501299) and ADIPOR1 (rs1342387 and rs12733285) and CRC susceptibility were evaluated.
|
25516230 |
2014 |
|
rs2241766
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Seven studies with 2,414 cases and 2,796 controls together did not show any significant association between SNP rs2241766</span> and CRC risk.
|
24293390 |
2014 |
|
rs2241766
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that adiponectin rs2241766T/G rather than rs1501299G/T, rs266729C/G, rs822395A/C and rs822396A/G polymorphism was associated with the risk of colorectal cancer.
|
23869187 |
2013 |
|
rs2241766
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In conclusion, the results showed that the ADIPOQ rs2241766 TG+GG genotype increased CRC risk.
|
23826253 |
2013 |
|
rs266729
|
|
|
0.060 |
GeneticVariation |
BEFREE |
<i>Conclusions</i>: Our findings show that APN rs266729 G/C polymorphism is associated with lower APN levels in CRC patients, indicating that decreased circulating levels of APN may be a determinant risk factor for CRC in MetS patients.
|
28529612 |
2017 |
|
rs266729
|
|
|
0.060 |
GeneticVariation |
BEFREE |
<i>Results</i>: We found that CRC patients (N=75) with genotype rs266729G/C or carriers of G allele were associated with a significantly increased risk of MetS development (OR =2.9) compared to those with CC genotype (N=30).
|
28529612 |
2017 |
|
rs266729
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our meta-analysis strongly suggests that the ADIPOQ rs2241766 T>G, rs1501299 G>T, and rs266729 C>G SNPs correlate with an increased risk of CRC.
|
26329379 |
2015 |
|
rs266729
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that adiponectin rs2241766T/G rather than rs1501299G/T, rs266729C/G, rs822395A/C and rs822396A/G polymorphism was associated with the risk of colorectal cancer.
|
23869187 |
2013 |
|
rs266729
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The SNP, rs266729, was not strongly associated with colorectal cancer in patients of Ashkenazi Jewish descent or other ethnic groups in Israel.
|
21829206 |
2011 |
|
rs266729
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A recent study examined common genetic variants at the adiponectin locus (ADIPOQ) in two case-control colorectal cancer (CRC) series from the USA and reported a positive association between a single nucleotide polymorphism (SNP) in the 5' region of the gene (rs266729) and decreased disease risk.
|
19264763 |
2009 |
|
rs266729
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The SNP rs266729, which tags the 5' flanking region of the ADIPOQ gene, is associated with decreased colorectal cancer risk.
|
18827209 |
2008 |
|
rs1501299
|
|
|
0.040 |
GeneticVariation |
BEFREE |
ADIPOQ rs2241766, ADIPOQ rs1501299 and CAPN-10 rs3792267 are significantly associated with CRC risk and the combination of the three polymorphisms and red meat affect CRC risk.
|
26203767 |
2015 |
|
rs1501299
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Results of the current meta-analysis revealed that the rs2241766 T>G single-nucleotide polymorphisms (SNP) increase the risk of CRC; rs1501299 G>T under dominant model was associated with increased risk of CRC; and rs266729 C>G SNP under allele model conferred an increased risk of CRC.
|
26329379 |
2015 |
|
rs1501299
|
|
|
0.040 |
GeneticVariation |
BEFREE |
After adjusting for factors such as colorectal cancer family history, body-mass index (BMI), daily sedentary time, weekly red meat intake frequency, as well regular tea drinking, conditional logistic regression analysis indicated that rs2241766 TG+GG carriers had a higher risk of colorectal cancer than TT carriers (OR=1.433, 95% CI: 1.014-1.985); rs1501299 GT+TT carriers had a lower risk of colorectal cancer than GG carriers (OR=0.723, 95% CI: 0.531-0.902).
|
25489716 |
2015 |
|
rs1501299
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The case-control study found no significant association for variants rs266729, rs822395, rs2241766, and rs1501299 on ADIPOQ or variant rs12733285 on ADIPOR1 and CRC susceptibility, which were consistent with results from the meta-analysis studies.
|
25516230 |
2014 |
|
rs822395
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With a hospital-based case-control study of 341 cases and 727 controls, the associations between the common variants on ADIPOQ (rs266729, rs822395, rs2241766 and rs1501299) and ADIPOR1 (rs1342387 and rs12733285) and CRC susceptibility were evaluated.
|
25516230 |
2014 |
|
rs822395
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that adiponectin rs2241766T/G rather than rs1501299G/T, rs266729C/G, rs822395A/C and rs822396A/G polymorphism was associated with the risk of colorectal cancer.
|
23869187 |
2013 |
|
rs822396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that adiponectin rs2241766T/G rather than rs1501299G/T, rs266729C/G, rs822395A/C and rs822396A/G polymorphism was associated with the risk of colorectal cancer.
|
23869187 |
2013 |