rs1801133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR rs1801133 polymorphism was not associated with the prognosis of patients with CRC; however, rs1801131 may be associated with the prognosis of patients with CRC.
|
31330573 |
2019 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study focused on understanding the prognostic value of the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms rs1801133 (C667T) and rs1801131 (A1298C) in patients with colorectal cancer (CRC).
|
31330573 |
2019 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this hospital-based case-control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age- and gender-matched healthy individuals.
|
29599316 |
2018 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis.
|
30131855 |
2018 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer.
|
29134491 |
2018 |
rs1801133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR rs1801133 T allele serves as a predictive marker for CRC risk and future studies with larger samples and functional evaluation are warranted to validate the current findings.
|
29599316 |
2018 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis.
|
30131855 |
2018 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this hospital-based case-control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age- and gender-matched healthy individuals.
|
29599316 |
2018 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Originally, there was no association between <i>MTHFR</i> C677T</span> polymorphism and CRC susceptibility (OR =0.99, 95% CI =0.94-1.05).
|
29089462 |
2017 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy.
|
28044213 |
2017 |
rs1801133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After excluding 13 studies according to their heterogeneity and publication bias, rs1801133 polymorphism was found to reduce the risks of CRC significantly (OR =0.96, 95% CI =0.94-0.99).
|
29089462 |
2017 |
rs1801133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results of this study showed that the rs1801394 alone or together with the rs1801133 is not a risk factor for CRC in Iranian population.
|
28691890 |
2017 |
rs1801133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, <i>MTHFR</i> rs1801133 G>A polymorphism confers a decreased risk to CRC.
|
28969008 |
2017 |
rs1801133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) for 498 CRC patients treated with 5-FU-based chemotherapy after receiving surgery.
|
28044213 |
2017 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although the MTHFR A1298C polymorphism was not associated with OS in CRC, this polymorphism was associated with significantly shorter OS in rectal cancer.
|
28044213 |
2017 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the MTHFR C677T polymorphism was associated with colorectal cancer (P<0.04) but not with gastric cancer.
|
27823653 |
2016 |
rs1801133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Never/occasional consumers of alcohol with the MTHFR rs1801133 CT/TT genotype were also at a reduced risk of CRC compared to never/occasional drinkers with the CC genotype (OR = 0.68, 95% CI, 0.47-0.98) (P for interaction = 0.27).
|
27827401 |
2016 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that MTHFR A1298C polymorphism is associated with increased cervical cancer and lymphoma risk in Asians, and MTHFR A1298C polymorphism is associated with decreased colorectal cancer risk in Asians.
|
26156333 |
2016 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggested that MTHFR C677T and A1298C are associated with prognosis in CRC patients undergoing 5-FU-based chemotherapy.
|
26111049 |
2015 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population.
|
26081619 |
2015 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer.
|
26564107 |
2015 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Evidence from the current meta-analysis indicated that the C677T polymorphism is not associated with CRC risk in Asian populations.
|
26745044 |
2015 |
rs1801133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present meta-analysis showed that rs1801133 and rs1801131 might be CRC susceptibility variants in Americans and Australians and rs1801133 in Brazilians and Japanese.
|
25823789 |
2015 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggested that MTHFR C677T and A1298C are associated with prognosis in CRC patients undergoing 5-FU-based chemotherapy.
|
26111049 |
2015 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects.
|
24193867 |
2014 |