Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801133
rs1801133
0.100 GeneticVariation BEFREE The MTHFR rs1801133 polymorphism was not associated with the prognosis of patients with CRC; however, rs1801131 may be associated with the prognosis of patients with CRC. 31330573

2019

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE The present study focused on understanding the prognostic value of the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms rs1801133 (C667T) and rs1801131 (A1298C) in patients with colorectal cancer (CRC). 31330573

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In this hospital-based case-control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age- and gender-matched healthy individuals. 29599316

2018

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis. 30131855

2018

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer. 29134491

2018

dbSNP: rs1801133
rs1801133
0.100 GeneticVariation BEFREE MTHFR rs1801133 T allele serves as a predictive marker for CRC risk and future studies with larger samples and functional evaluation are warranted to validate the current findings. 29599316

2018

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis. 30131855

2018

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE In this hospital-based case-control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age- and gender-matched healthy individuals. 29599316

2018

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Originally, there was no association between <i>MTHFR</i> C677T</span> polymorphism and CRC susceptibility (OR =0.99, 95% CI =0.94-1.05). 29089462

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy. 28044213

2017

dbSNP: rs1801133
rs1801133
0.100 GeneticVariation BEFREE After excluding 13 studies according to their heterogeneity and publication bias, rs1801133 polymorphism was found to reduce the risks of CRC significantly (OR =0.96, 95% CI =0.94-0.99). 29089462

2017

dbSNP: rs1801133
rs1801133
0.100 GeneticVariation BEFREE Results of this study showed that the rs1801394 alone or together with the rs1801133 is not a risk factor for CRC in Iranian population. 28691890

2017

dbSNP: rs1801133
rs1801133
0.100 GeneticVariation BEFREE However, <i>MTHFR</i> rs1801133 G>A polymorphism confers a decreased risk to CRC. 28969008

2017

dbSNP: rs1801133
rs1801133
0.100 GeneticVariation BEFREE We genotyped MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) for 498 CRC patients treated with 5-FU-based chemotherapy after receiving surgery. 28044213

2017

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE Although the MTHFR A1298C polymorphism was not associated with OS in CRC, this polymorphism was associated with significantly shorter OS in rectal cancer. 28044213

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We found that the MTHFR C677T polymorphism was associated with colorectal cancer (P<0.04) but not with gastric cancer. 27823653

2016

dbSNP: rs1801133
rs1801133
0.100 GeneticVariation BEFREE Never/occasional consumers of alcohol with the MTHFR rs1801133 CT/TT genotype were also at a reduced risk of CRC compared to never/occasional drinkers with the CC genotype (OR = 0.68, 95% CI, 0.47-0.98) (P for interaction = 0.27). 27827401

2016

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE In summary, this meta-analysis suggests that MTHFR A1298C polymorphism is associated with increased cervical cancer and lymphoma risk in Asians, and MTHFR A1298C polymorphism is associated with decreased colorectal cancer risk in Asians. 26156333

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This study suggested that MTHFR C677T and A1298C are associated with prognosis in CRC patients undergoing 5-FU-based chemotherapy. 26111049

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population. 26081619

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer. 26564107

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Evidence from the current meta-analysis indicated that the C677T polymorphism is not associated with CRC risk in Asian populations. 26745044

2015

dbSNP: rs1801133
rs1801133
0.100 GeneticVariation BEFREE The present meta-analysis showed that rs1801133 and rs1801131 might be CRC susceptibility variants in Americans and Australians and rs1801133 in Brazilians and Japanese. 25823789

2015

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE This study suggested that MTHFR C677T and A1298C are associated with prognosis in CRC patients undergoing 5-FU-based chemotherapy. 26111049

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects. 24193867

2014