Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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T | 0.700 | CausalMutation | CLINVAR | Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials. | 22162582 | 2012 |
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T | 0.700 | CausalMutation | CLINVAR | Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. | 22162589 | 2012 |
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T | 0.700 | CausalMutation | CLINVAR | Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. | 20453058 | 2010 |
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T | 0.700 | CausalMutation | CLINVAR | Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. | 20619739 | 2010 |
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T | 0.700 | CausalMutation | CLINVAR | PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. | 19366826 | 2009 |
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T | 0.700 | CausalMutation | CLINVAR | PIK3CA mutations predict local recurrences in rectal cancer patients. | 19903786 | 2009 |
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T | 0.700 | CausalMutation | CLINVAR | Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. | 18725974 | 2008 |
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T | 0.700 | CausalMutation | CLINVAR | Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. | 15647370 | 2005 |
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T | 0.700 | CausalMutation | CLINVAR | The PIK3CA gene is mutated with high frequency in human breast cancers. | 15254419 | 2004 |
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T | 0.700 | CausalMutation | CLINVAR | High frequency of mutations of the PIK3CA gene in human cancers. | 15016963 | 2004 |