|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the protective HO1 promoter polymorphism correlates with a lower coronary artery plaque burden, whereas the protective ENOS 894 G/T polymorphism seems to favourably influence changes of coronary artery plaque composition during statin therapy, but has no significant correlation to the magnitude of coronary atherosclerosis.
|
22123460 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
G894T polymorphism of eNOS gene was not associated with foot ulcer and diabetic complications, except in the presence of atherosclerotic heart disease.
|
20642368 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study, for the first time, suggests an independent association of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in a Saudi population.
|
20470943 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of endothelial nitric oxide synthase gene variant (G894T) with coronary artery disease in Western Iran.
|
21602253 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase (eNOS), which produces NO, plays an important role in the endothelial function under a wide range of physiological conditions. eNOS exon 7 polymorphism (Glu298Asp, G894T) has been considered to influence the risk of coronary artery disease.
|
15595935 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Caucasians, association between E298D genotype and risk of coronary heart disease was significantly modified by current smoking status (interaction P=0.013), with the highest risk observed in smokers carrying the variant D298 allele relative to nonsmokers carrying two E298 alleles (adjusted hazard rate ratio 2.07, 95% confidence interval 1.39-3.07).
|
17108813 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, there was evidence that small studies with more striking results could affect the associations of the Glu298Asp and -786T>C polymorphisms with coronary heart disease.
|
17018701 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK.
|
10510054 |
1999 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
NO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish population.
|
15483745 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Lack of association between the Glu298Asp variant of the endothelial nitric oxide synthase gene and the risk of coronary artery disease among Taiwanese.
|
11802531 |
2001 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The eNOS -786T>C (odds ratio [OR]; 1.61, 95% confidence interval [CI]; 0.97-2.69), 894G>T (OR; 1.12, 95% CI; 0.65-1.92) and 4a4b (OR; 1.44, 95% CI; 0.87-2.39) polymorphisms were not an independent predisposition factor to coronary artery disease.
|
16842840 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients.
|
27613099 |
2016 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.
|
22417945 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a meta‑analysis of 39 case‑control studies.
|
23443250 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An endothelial nitric oxide synthase gene (NOS3) polymorphism in exon 7 (G894T), resulting in Glu298Asp substitution at protein level, has been associated with myocardial infarction, hypertension and coronary atherosclerosis in some populations.
|
12113283 |
2002 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Glu-298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease.
|
10475066 |
1999 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians.
|
30789045 |
2019 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations.
|
12641536 |
2003 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease.
|
22045428 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-onset coronary artery disease.
|
11579346 |
2001 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Glu298-->Asp polymorphism of the eNOS gene appears to be associated with the presence, extent, and severity of angiographically assessed coronary artery disease.
|
12010932 |
2002 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease.
|
24827774 |
2014 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a common polymorphism in exon 7 of the eNOS gene (894G-->T) has been reported to be a strong risk factor for coronary artery disease.
|
9731617 |
1998 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A missense mutation of the nitric oxide synthase (eNOS) gene (Glu298Asp) in five patients with coronary artery disease--case reports.
|
10451235 |
1999 |