Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In this generally well-nourished population, men with the +/+ genotype for the C677T mutation in the methylenetetrahydrofolate reductase gene have no increase in risk of coronary heart disease, even when intake of folate or other B vitamins is low. 9708460

1998

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Prevalence and role of methylenetetrahydrofolate reductase 677 C-->T and 1298 A-->C polymorphisms in coronary artery disease in Arabs. 14521457

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization. 17604826

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease. 15353918

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The association of MTHFR C677T gene variants and lipid profiles or body mass index in patients with diabetic and nondiabetic coronary heart disease. 24218123

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We investigated the influence of elevated homocysteine plasma levels and 2 polymorphisms, 677C/T and 1298A/C, of the methylenetetrahydrofolate reductase (MTHFR) gene on the risk of restenosis after stenting in patients with symptomatic coronary artery disease. 14604831

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes. 18586656

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE No strong evidence exists to support an association of the MTHFR 677 C-->T polymorphism and coronary heart disease in Europe, North America, or Australia. 16216822

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase C677T gene polymorphism and coronary artery disease in a Chinese Han population: a meta-analysis. 22146089

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease. 27051002

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with early onset of coronary artery disease in some populations with certain ethnic backgrounds. 18751630

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians. 22664498

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population. 15935452

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The present study extends previous observations by the finding that carriers of the N5,N10-methylenetetrahydrofolate reductase C677T TT genotype with various coronary high risk profiles had clearly higher coronary heart disease scores than individuals with at least one C677T C allele. 10337543

1999

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C-->T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy). 15447919

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease. 12522558

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid. 12801615

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease. 15648053

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE One putative determinant of PAD is the 677C>T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), which has previously been found to associate with various diabetic complications including retinopathy, nephropathy, atherosclerosis and coronary heart disease. 16274479

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Detection of C677T mutation of MTHFR in subject with coronary heart disease by hairpin probe with enzymatic color on microarray. 21802936

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase 677 C-->T mutation and coronary heart disease risk in UK Indian Asians. 11073851

2000

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Recent studies have shown that a common mutation (nucleotide 677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene may contribute to a mild rise in plasma homocysteine levels and increase the incidence of coronary artery disease. 16489563

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T mutation in methylenetetrahydrofolate reductase gene, plasma homocysteine concentration and the risk of coronary artery disease. 14560345

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The oxidative modification of low-density lipoprotein (LDL) has been suggested to be a key element in atherogenesis, while methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated with the development of coronary heart disease. 16487909

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians. 26095803

2015