Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians. 30789045

2019

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In addition, we also found that the rs1799983 polymorphism was significantly associated with the susceptibility to peripheral artery disease, whereas the rs2070744 polymorphism was significantly associated with the susceptibility to coronary artery disease in DM patients. 30140993

2018

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Association Patterns of Endothelial Nitric Oxide Synthase Gene (NOS3) Variant Glu298Asp with Blood Pressure and Serum Lipid Levels in Subjects with Coronary Artery Disease from Pakistan. 28620990

2017

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients. 27613099

2016

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE On the basis of present results, it can be concluded that rs1799</span>983 is strongly associated with coronary artery disease in our population and TT genotype of this polymorphism enhanced the risk of coronary artery disease in Pakistani population. 25057159

2015

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). 26256966

2015

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease. 24827774

2014

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a meta‑analysis of 39 case‑control studies. 23443250

2013

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Association of endothelial nitric oxide synthase gene variant (G894T) with coronary artery disease in Western Iran. 21602253

2012

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis. 22417945

2012

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. 21816783

2011

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In conclusion, the protective HO1 promoter polymorphism correlates with a lower coronary artery plaque burden, whereas the protective ENOS 894 G/T polymorphism seems to favourably influence changes of coronary artery plaque composition during statin therapy, but has no significant correlation to the magnitude of coronary atherosclerosis. 22123460

2011

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease. 22045428

2011

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE G894T polymorphism of eNOS gene was not associated with foot ulcer and diabetic complications, except in the presence of atherosclerotic heart disease. 20642368

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE This study, for the first time, suggests an independent association of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in a Saudi population. 20470943

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The G894T polymorphism in the eNOS gene might influence coronary atherosclerosis rather than ICAS in Koreans. 21114134

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial. 20083095

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Relationship between hemorheology and Glu(298)Asp polymorphism of endothelial nitric oxide synthase gene in patients with coronary artery disease. 19434512

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The eNOS -786T>C (odds ratio [OR]; 1.61, 95% confidence interval [CI]; 0.97-2.69), 894G>T (OR; 1.12, 95% CI; 0.65-1.92) and 4a4b (OR; 1.44, 95% CI; 0.87-2.39) polymorphisms were not an independent predisposition factor to coronary artery disease. 16842840

2007

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In Caucasians, association between E298D genotype and risk of coronary heart disease was significantly modified by current smoking status (interaction P=0.013), with the highest risk observed in smokers carrying the variant D298 allele relative to nonsmokers carrying two E298 alleles (adjusted hazard rate ratio 2.07, 95% confidence interval 1.39-3.07). 17108813

2006

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE However, there was evidence that small studies with more striking results could affect the associations of the Glu298Asp and -786T>C polymorphisms with coronary heart disease. 17018701

2006

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls. 16616056

2006

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Endothelial nitric oxide synthase (eNOS), which produces NO, plays an important role in the endothelial function under a wide range of physiological conditions. eNOS exon 7 polymorphism (Glu298Asp, G894T) has been considered to influence the risk of coronary artery disease. 15595935

2005

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE NO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish population. 15483745

2004

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations. 12641536

2003