Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5742904
rs5742904
0.010 GeneticVariation BEFREE None of the 274 individuals in the coronary heart disease (CHD) groups was found to be a carrier of the apoB allele Arg3500----Gln, previously shown to be associated with an apoB protein defective in binding to the low density lipoprotein receptor (LDL-R). 1346774

1992

dbSNP: rs5182
rs5182
0.010 GeneticVariation BEFREE In a preliminary study we found no association between the distribution of the C/T573 polymorphic site and cardiovascular disease, such as essential hypertension (n = 20) coronary artery disease (n = 16) hypertrophic cardiomyopathy (n = 12) or dilated cardiomyopathy (n = 21). 7713099

1994

dbSNP: rs751377893
rs751377893
F5
0.030 GeneticVariation BEFREE Evidence against heterozygous coagulation factor V 1691 G-->A mutation with resistance to activated protein C being a risk factor for coronary artery disease and myocardial infarction. 8581514

1995

dbSNP: rs2303790
rs2303790
0.030 GeneticVariation BEFREE Thus, genetic CETP deficiency appears to be an independent risk factor for CHD, primarily due to increased CHD prevalence in men with the D442G mutation and HDL cholesterol between 41 and 60 mg/dl. 8675707

1996

dbSNP: rs1801177
rs1801177
LPL
0.020 GeneticVariation BEFREE Two common coding sequence mutations of lipoprotein lipase (serine447-ter, producing a carboxy terminal truncation; and asp9-asn variants) were studied in 329 Caucasian subjects, of whom 243 had angiographic features of premature atheroscelerosis (220 with coronary artery disease; 23 with coronary and peripheral artery disease). 8835323

1995

dbSNP: rs1384889210
rs1384889210
0.010 GeneticVariation BEFREE Compound heterozygosity for a structural apolipoprotein A-I variant, apo A-I(L141R)Pisa, and an apolipoprotein A-I null allele in patients with absence of HDL cholesterol, corneal opacifications, and coronary heart disease. 8840853

1996

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE It has been hypothesized an A/B (Gln 192-->Arg) polymorphism of PON may be involved in the pathogenesis of CHD, especially among subjects with non-insulin-dependent diabetes mellitus (NIDDM). 8960946

1996

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE A common mutation (nucleotide 677 C-->T) has been described recently in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, which results in a valine for alanine substitution, a thermolabile enzyme, and a tendency to elevate plasma homocysteine levels and which has been proposed to contribute importantly to coronary artery disease. 8994411

1997

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD. 9020385

1997

dbSNP: rs1458766475
rs1458766475
0.090 GeneticVariation BEFREE We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD. 9020385

1997

dbSNP: rs5361
rs5361
0.090 GeneticVariation BEFREE We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD. 9020385

1997

dbSNP: rs1267969615
rs1267969615
ACE
0.080 GeneticVariation BEFREE We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD. 9020385

1997

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE This case-control study was initiated to investigate whether the ACEI/D and AGT M235T polymorphisms are associated with an increased risk for coronary heart disease (CHD) and MI. 9034401

1997

dbSNP: rs1267969615
rs1267969615
ACE
0.080 GeneticVariation BEFREE This case-control study was initiated to investigate whether the ACEI/D and AGT M235T polymorphisms are associated with an increased risk for coronary heart disease (CHD) and MI. 9034401

1997

dbSNP: rs1264352930
rs1264352930
0.010 GeneticVariation BEFREE Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease. 9125314

1996

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We tested the effects of a 3-week daily intake of 1 or 2 mg of FA supplements on tHcy levels in patients with and without coronary heart disease (CHD) who were analyzed for the C677T MTHFR mutation. 9194768

1997

dbSNP: rs267606661
rs267606661
0.010 GeneticVariation BEFREE Apolipoprotein E R112; R251G: a carboxy-terminal variant found in patients with hyperlipidemia and coronary heart disease. 9360638

1997

dbSNP: rs7493
rs7493
0.060 GeneticVariation BEFREE In this report, we describe the existence of a common polymorphism at codon 311 (Cys-->Ser; PON2*S) in the PON2 gene, as well as its association with CHD alone and in combination with the PON1 codon 192 polymorphism in Asian Indians. 9443862

1998

dbSNP: rs1799883
rs1799883
0.010 GeneticVariation BEFREE The allele frequency of an amino acid polymorphism (alanine-->threonine) in codon 54 of exon 2 of the FABP2 gene was 0.26 in nondiabetic subjects with CHD and 0.27 in NIDDM subjects with CHD. 9589253

1998

dbSNP: rs773641005
rs773641005
0.010 GeneticVariation BEFREE The allele frequency of an amino acid polymorphism (alanine-->threonine) in codon 54 of exon 2 of the FABP2 gene was 0.26 in nondiabetic subjects with CHD and 0.27 in NIDDM subjects with CHD. 9589253

1998

dbSNP: rs5882
rs5882
0.070 GeneticVariation BEFREE In this study we determined the relationship between a common CETP amino acid polymorphism (I405V) and CETP and HDL levels and CHD prevalence in 576 men of Japanese ancestry in the Honolulu Heart Program cohort. 9610775

1998

dbSNP: rs4762
rs4762
AGT
0.050 GeneticVariation BEFREE We suggest that the angiotensinogen T174M allele might be associated with insulin resistance in nondiabetic men with and without CHD. 9665229

1998

dbSNP: rs1458766475
rs1458766475
0.090 GeneticVariation BEFREE All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study). 9668170

1998

dbSNP: rs5361
rs5361
0.090 GeneticVariation BEFREE All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study). 9668170

1998

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE There was no association of CHD with the C677T mutation of the methylenetetrahydrofolate reductase gene or with 3 mutations of the cystathionine beta-synthase gene. 9697819

1998