rs5742904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
None of the 274 individuals in the coronary heart disease (CHD) groups was found to be a carrier of the apoB allele Arg3500----Gln, previously shown to be associated with an apoB protein defective in binding to the low density lipoprotein receptor (LDL-R).
|
1346774 |
1992 |
rs5182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a preliminary study we found no association between the distribution of the C/T573 polymorphic site and cardiovascular disease, such as essential hypertension (n = 20) coronary artery disease (n = 16) hypertrophic cardiomyopathy (n = 12) or dilated cardiomyopathy (n = 21).
|
7713099 |
1994 |
rs751377893
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Evidence against heterozygous coagulation factor V 1691 G-->A mutation with resistance to activated protein C being a risk factor for coronary artery disease and myocardial infarction.
|
8581514 |
1995 |
rs2303790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Thus, genetic CETP deficiency appears to be an independent risk factor for CHD, primarily due to increased CHD prevalence in men with the D442G mutation and HDL cholesterol between 41 and 60 mg/dl.
|
8675707 |
1996 |
rs1801177
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two common coding sequence mutations of lipoprotein lipase (serine447-ter, producing a carboxy terminal truncation; and asp9-asn variants) were studied in 329 Caucasian subjects, of whom 243 had angiographic features of premature atheroscelerosis (220 with coronary artery disease; 23 with coronary and peripheral artery disease).
|
8835323 |
1995 |
rs1384889210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Compound heterozygosity for a structural apolipoprotein A-I variant, apo A-I(L141R)Pisa, and an apolipoprotein A-I null allele in patients with absence of HDL cholesterol, corneal opacifications, and coronary heart disease.
|
8840853 |
1996 |
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It has been hypothesized an A/B (Gln 192-->Arg) polymorphism of PON may be involved in the pathogenesis of CHD, especially among subjects with non-insulin-dependent diabetes mellitus (NIDDM).
|
8960946 |
1996 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common mutation (nucleotide 677 C-->T) has been described recently in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, which results in a valine for alanine substitution, a thermolabile enzyme, and a tendency to elevate plasma homocysteine levels and which has been proposed to contribute importantly to coronary artery disease.
|
8994411 |
1997 |
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD.
|
9020385 |
1997 |
rs1458766475
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD.
|
9020385 |
1997 |
rs5361
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD.
|
9020385 |
1997 |
rs1267969615
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD.
|
9020385 |
1997 |
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This case-control study was initiated to investigate whether the ACEI/D and AGT M235T polymorphisms are associated with an increased risk for coronary heart disease (CHD) and MI.
|
9034401 |
1997 |
rs1267969615
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This case-control study was initiated to investigate whether the ACEI/D and AGT M235T polymorphisms are associated with an increased risk for coronary heart disease (CHD) and MI.
|
9034401 |
1997 |
rs1264352930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease.
|
9125314 |
1996 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the effects of a 3-week daily intake of 1 or 2 mg of FA supplements on tHcy levels in patients with and without coronary heart disease (CHD) who were analyzed for the C677T MTHFR mutation.
|
9194768 |
1997 |
rs267606661
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Apolipoprotein E R112; R251G: a carboxy-terminal variant found in patients with hyperlipidemia and coronary heart disease.
|
9360638 |
1997 |
rs7493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In this report, we describe the existence of a common polymorphism at codon 311 (Cys-->Ser; PON2*S) in the PON2 gene, as well as its association with CHD alone and in combination with the PON1 codon 192 polymorphism in Asian Indians.
|
9443862 |
1998 |
rs1799883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele frequency of an amino acid polymorphism (alanine-->threonine) in codon 54 of exon 2 of the FABP2 gene was 0.26 in nondiabetic subjects with CHD and 0.27 in NIDDM subjects with CHD.
|
9589253 |
1998 |
rs773641005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele frequency of an amino acid polymorphism (alanine-->threonine) in codon 54 of exon 2 of the FABP2 gene was 0.26 in nondiabetic subjects with CHD and 0.27 in NIDDM subjects with CHD.
|
9589253 |
1998 |
rs5882
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In this study we determined the relationship between a common CETP amino acid polymorphism (I405V) and CETP and HDL levels and CHD prevalence in 576 men of Japanese ancestry in the Honolulu Heart Program cohort.
|
9610775 |
1998 |
rs4762
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We suggest that the angiotensinogen T174M allele might be associated with insulin resistance in nondiabetic men with and without CHD.
|
9665229 |
1998 |
rs1458766475
|
|
|
0.090 |
GeneticVariation |
BEFREE |
All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study).
|
9668170 |
1998 |
rs5361
|
|
|
0.090 |
GeneticVariation |
BEFREE |
All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study).
|
9668170 |
1998 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no association of CHD with the C677T mutation of the methylenetetrahydrofolate reductase gene or with 3 mutations of the cystathionine beta-synthase gene.
|
9697819 |
1998 |