Considering that the rs2119289 of FIGN gene is related to the appropriate folate level, FIGN might play an important role in CHD by upregulating plasma folate concentration during embryo heart development.
The +94762G>C (rs2119289) variant in intron 4 of the <i>FIGN</i> gene was associated with significant reduction in CHD susceptibility (<i>P</i>=5.1×10<sup>-14</sup> for the allele, <i>P</i>=8.5×10<sup>--13</sup> for the genotype).