|
rs2097432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genetic variation HLADQA1*05 (rs2097432) has been linked to infliximab antibody formation in Crohn's disease (CD).
|
31650614 |
2020 |
|
rs6754677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele and homozygous G/G genotype of the rs6754677 G/A polymorphism were protective in the Indian population, whereas the homozygous A/A genotype showed a risk of developing CD.
|
31654602 |
2020 |
|
rs10249788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant differences were observed in allele and genotype frequencies of rs2066853 and rs10249788 between patients with CD and the controls (all <i>p</i> > 0.05).
|
31405308 |
2019 |
|
rs1734907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While colocalization analyses were inconclusive, functional characterization of these variants provided the strongest evidence for a model in which genetic variation at rs1734907 modulates risk of schizophrenia and Crohn's disease via altered methylation and expression of EPHB4-a gene whose protein product guides the migration of neuronal axons in the brain and the migration of lymphocytes towards infected cells in the immune system.
|
31211845 |
2019 |
|
rs17525495
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T allele of <i>LTA4H</i> gene SNP (rs17525495) is a risk factor for Crohn's disease</span> instead of intestinal tuberculosis.
|
31093505 |
2019 |
|
rs200550971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CB2-Q63R variant contributes to the risk for pediatric IBD, in particular CD.
|
27875353 |
2019 |
|
rs2066853
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant differences were observed in allele and genotype frequencies of rs2066853 and rs10249788 between patients with CD and the controls (all <i>p</i> > 0.05).
|
31405308 |
2019 |
|
rs2158041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although rs2158041 and rs10249788 were in complete linkage disequilibrium with rs2066853, respectively, only the frequency of haplotype (TG) formed by rs2158041 and rs2066853 was significantly lower in patients with CD than that in the controls (<i>p < </i>0.05).
|
31405308 |
2019 |
|
rs2294021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant alleles of rs3761547, rs2232365, and rs2294021 were less in male patients with stricturing CD compared to those with non-stricturing, non-penetrating CD; however, these variants were frequently detected in male patients with colonic CD than in those with ileocolonic CD.
|
30710380 |
2019 |
|
rs2501432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CB2-Q63R variant contributes to the risk for pediatric IBD, in particular CD.
|
27875353 |
2019 |
|
rs3129891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, both lysozyme and secretory phospholipase A2 in UC and CD were unaffected by rs3129891 and rs77005575 genotypes.
|
31403980 |
2019 |
|
rs34436714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to investigate the impact of the single nucleotide polymorphisms of rs34436714 of the NOD-like receptor protein 12 gene on the production of tumor necrosis factor-alpha (TNFα) in patients with inflammatory bowel disease (IBD)In a matched case-control study 90 patients with IBD, 56 with Crohn disease (CD) and 34 with ulcerative colitis, were genotyped and compared to 98 healthy comparators matched for age and gender.
|
31169706 |
2019 |
|
rs35761398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CB2-Q63R variant contributes to the risk for pediatric IBD, in particular CD.
|
27875353 |
2019 |
|
rs3731772
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs72553867, located in the IRGM gene on chromosome 5, rs4409764, located in the NKX2-3 gene on chromosome 10, and rs3731772, located in the AOX1 gene on chromosome 2, were susceptibility factors for pCD.
|
31844038 |
2019 |
|
rs3761548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant allele of rs3761548 was increased in male patients with penetrating CD compared to those with non-stricturing, non-penetrating CD.
|
30710380 |
2019 |
|
rs755918883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, these results suggest a potential role for ZIP8 in intestinal inflammation, induced by IFNγ in the intestinal epithelial compartment, and that perturbations in negative regulation of NF-κB by ZIP8 A391T may contribute to CD pathogenesis.
|
31151823 |
2019 |
|
rs879761216
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CB2-Q63R variant contributes to the risk for pediatric IBD, in particular CD.
|
27875353 |
2019 |
|
rs9144
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the Crohn's disease activity index at the first infliximab use and rs9144 (P = 0.001) were independently associated with the loss of response in patients with Crohn's disease.
|
30851117 |
2019 |
|
rs1159782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
JAK2 rs1159782 (T>C) was also strongly associated with Crohn's disease (P = 2.34 × 10<sup>-4</sup> ; odds ratio = 3.72).
|
29441677 |
2018 |
|
rs12343867
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
rs1321402467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (SNP) c.415C>T in exon 3 of <i>NUDT15</i> affects thiopurine-induced leukopenia in Asian patients with Crohn's disease.
|
29398872 |
2018 |
|
rs145566594
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that both CD subjects and mice with ATG16L1T300A (T300A; a prevalent CD susceptibility allele) developed Paneth cell defects triggered by tobacco smoke.
|
30137026 |
2018 |
|
rs16969968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, interaction between rs16969968 and smoking in predicting surgery was observed for both UC (OR = 2.72; P = 0.05) and CD (OR = 2.88; P = 0.1).
|
29688464 |
2018 |
|
rs17250932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
rs1800947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study demonstrates that rs2794520 and rs1800947 are associated with a restriction of CRP elevations during active CD.
|
29718222 |
2018 |