|
rs1000113
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Our analysis revealed an association of the IRGM SNPs rs13371189 (p = 0.02, OR 1.31 [95% CI 1.05-1.65]), rs10065172 = p.Leu105Leu (p = 0.016, OR 1.33 [95% CI 1.06-1.66]) and rs1000113 (p = 0.047, OR 1.27 [95% CI 1.01-1.61]) with CD susceptibility.
|
23365659 |
2013 |
|
rs1000113
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Significant associations with Crohn's disease were noted with the T allele of rs1000113 (OR 1.46, 95% CI 1.12-1.90), T allele of rs9637876 (OR 1.25, 95% CI 1.005-1.561) and C allele of rs 13361189 (OR 1.33, 95% CI 1.07-1.669).
|
25191865 |
2014 |
|
rs1000113
|
|
T |
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
rs1000113
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We replicated the previously reported associations between CD and rs1000113 and rs4958847, confirming that IRGM is a susceptibility locus only for CD, either adult- or early-onset in the Italian population; furthermore, we have also shown its influence on specific clinical features (fistulizing disease).
|
19098858 |
2009 |
|
rs1000113
|
|
|
0.840 |
GeneticVariation |
BEFREE |
IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset CD as risk loci and defense loci, respectively.
|
25944217 |
2015 |
|
rs1000113
|
|
T |
0.840 |
GeneticVariation |
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
rs1001007
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs1002922
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
|
17447842 |
2007 |
|
rs1004234
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs10045431
|
|
C |
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs10045431
|
|
C |
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs10045431
|
|
|
0.810 |
GeneticVariation |
GWASDB |
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
20570966 |
2010 |
|
rs10045431
|
|
|
0.810 |
GeneticVariation |
BEFREE |
MAP, rs2241880 (ATG16L1) and rs10045431 (IL12B) were found to be significantly associated with CD.
|
24522266 |
2014 |
|
rs10045431
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
20570966 |
2010 |
|
rs1004819
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The association of ATG16L1 T300A with CD was confirmed [P = 0.004, odds ratio (OR) = 1.69, 95% CI: 1.19-2.41], and both IL23R variants were found to represent significant risk for the disease (P = 0.008, OR = 2.05, 95% CI: 1.20-3.50 for rs1004819 AA; P < 0.001, OR = 2.97, 95% CI: 1.65-5.33 for rs2201841 CC).
|
20066736 |
2010 |
|
rs1004819
|
|
|
0.860 |
GeneticVariation |
BEFREE |
This study was aimed to investigate the possible association of Crohn's disease (CD) with inflammatory bowel disease gene 5 (IBD5) IGR2198a_1 (rs11739135), IGR2096a_1 (rs12521868) and interleukin-23 receptor (IL23R) genetic variant (rs1004819) in the Malaysian population.
|
22908971 |
2012 |
|
rs1004819
|
|
|
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
rs1004819
|
|
|
0.860 |
GeneticVariation |
BEFREE |
IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5. rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC.
|
17786191 |
2007 |
|
rs1004819
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Two IL23R gene variants, an intronic SNP rs1004819 and intergenic SNP rs1495465, showed significant associations with CD; the adjusted odds ratio (aOR) for rs1004819 was 1.822 (95% confidence interval [CI] = 1.164-2.852, P = 0.009) and aOR for rs1495965 was 1.650 (95% CI = 1.102-2.471, P = 0.015).
|
19334001 |
2009 |
|
rs1004819
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Allele rs1004819: A was also significantly more frequent in Poles with penetrating CD.
|
31052515 |
2019 |
|
rs1004819
|
|
|
0.860 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
rs1004819
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Significant gene-gene interactions were also observed for the TLR9 polymorphism -1237T/C with IL23R variants (most significantly with rs1004819, P=0.0007), with a particular high frequency of -1237C in CD patients carrying CD-protective IL23R variants.
|
19455129 |
2009 |
|
rs10051722
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
rs10063949
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A genetic variant (rs10063949-G) in the SLC23A1 ascorbate transporter locus was identified and is associated with an increased risk of CD in a white Canadian IBD cohort.
|
24284447 |
2014 |
|
rs10065172
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls.
|
21283700 |
2011 |