|
rs2542151
|
|
|
0.880 |
GeneticVariation |
GWASDB |
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.
|
21298027 |
2011 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
BEFREE |
PTPN2 (rs2542151) was only associated in the smoking CD cohort (P=0.041), and not in the entire cohort (P=0.23) or in the non-smoking CD cohort (P=0.80).
|
19953089 |
2010 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
GWASCAT |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |
|
rs2542151
|
|
G |
0.880 |
GeneticVariation |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) results in a dysfunctional PTPN2 protein is associated with Crohn's disease (CD) and exists in perfect linkage disequilibrium with the CD- and ulcerative colitis (UC)-associated PTPN2 SNP rs2542151.
|
26928573 |
2016 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.
|
22426692 |
2012 |
|
rs2542151
|
|
G |
0.880 |
GeneticVariation |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
BEFREE |
In stage 1, we observed associations between 5 intronic SNPs and CD including rs1893217 (P = 2 × 10⁻⁴), the SNP that is in perfect linkage disequilibrium with the lead genome-wide association studies SNP rs2542151.
|
23518806 |
2013 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Both rs2542151 and rs2542152 are associated with CD, but not ulcerative colitis (UC). mRNA expression levels of PTPN2 were significantly increased in intestinal tissues (p=0.0493), and nearly significantly increased in B cells (p=0.0889) from CD patients, but not significantly altered in UC. cDNA microarray results found that PTPN2 was down-regulated by NKX2-3 knockdown in human cells.
|
22377701 |
2012 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis.
|
22021207 |
2012 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Significant associations were found between rs2542151 polymorphism and CD susceptibility (OR = 1.22, 95 % CI, 1.15-1.30, I (2) = 32 %), as well as between rs2542151 and UC susceptibility (OR = 1.16, 95 % CI, 1.07-1.25, I (2) = 39 %).
|
24127071 |
2014 |
|
rs2542151
|
|
G |
0.880 |
GeneticVariation |
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
rs2542151
|
|
G |
0.880 |
GeneticVariation |
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Our analysis revealed a significant association of PTPN2 SNP rs2542151 with both susceptibility to CD (p = 1.95×10⁻⁵; OR 1.49 [1.34-1.79]) and UC (p = 3.87×10⁻², OR 1.31 [1.02-1.68]).
|
22457781 |
2012 |
|
rs2542151
|
|
|
0.880 |
GeneticVariation |
GWASDB |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |
|
rs10758669
|
|
C |
0.850 |
GeneticVariation |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs10758669
|
|
|
0.850 |
GeneticVariation |
BEFREE |
For the JAK2 rs10758669 polymorphism, the homozygous C/C or heterozygous A/C genotypes increased the risk of having CD as compared with the homozygous A/A (OR=1.76, 95% CI=1.26-2.45 and OR=2.36, 95% CI=1.44-3.86, respectively, p=0.0003).
|
20109474 |
2010 |
|
rs10758669
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Additionally, rs10758669</span> and rs2293152 in Crohn's disease and rs8074524, rs3816769, and rs10758669 in ulcerative colitis were associated with the requirement of immunsuppression.
|
27852544 |
2016 |
|
rs10758669
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients.
|
22269120 |
2012 |
|
rs10758669
|
|
C |
0.850 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
rs10758669
|
|
C |
0.850 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
rs10758669
|
|
|
0.850 |
GeneticVariation |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs10758669
|
|
|
0.850 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that JAK2 rs10758669 polymorphism was a risk factor both for CD and UC, especially in Caucasian.
|
24385239 |
2014 |
|
rs10758669
|
|
C |
0.850 |
GeneticVariation |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs10758669
|
|
|
0.850 |
GeneticVariation |
BEFREE |
JAK2 rs10758669 and STAT3 rs744166 increase susceptibility for CD.
|
22065112 |
2012 |