DisGeNET - a database of gene-disease associations

Crohn Disease, C0010346

Gene: NCF4 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs4821544

NCF4 ; NCF4-AS1

0.720

GeneticVariation

GWASCAT

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

28067908

2017

dbSNP:

rs4821544

NCF4 ; NCF4-AS1

0.720

GeneticVariation

BEFREE

This meta-analysis suggested that the rs4821544T/C polymorphism was associated with CD, but not UC in Caucasian.

26289093

2015

dbSNP:

rs4821544

NCF4 ; NCF4-AS1

0.720

GeneticVariation

BEFREE

NCF4 and IRGM were significantly associated with ileal CD (P-value(rs4821544)=0.0090, odds ratio (OR)=1.425, 95% confidence interval (CI): 1.092-1.859; P-value(rs13361189)=0.0017, OR=1.942, 95% CI: 1.274-2.959; P-value(rs4958847)=0.0022, OR=1.767, 95% CI: 1.224-2.558), but not with other forms of inflammatory bowel disease (IBD).

18580884

2008