Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE All the genetic models of rs11209026 polymorphism significantly decrease CD and UC risk (except for the recessive model in UC) (p < 0.05). 31728561

2020

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Specifically the G149R, V362I, and R381Q IL23Rα chain variants are linked to protection against the development of Crohn disease and ulcerative colitis in humans. 26887945

2016

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE NOD2 p.L1007insC was associated with OFG+CD (P = 0.023) and IL23R p.R381Q with all OFG (P = 0.031). 27306066

2016

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Finally, rs8074524 and rs10758669 in Crohn's disease and rs11209026 in ulcerative colitis were associated with disease-related operation. 27852544

2016

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Interestingly, a functional single nucleotide polymorphism (SNP) in the IL-23 receptor gene (IL-23R; rs11209026, 1142 G wild-type A reduced function, Arg381Gln, R381Q) seems to confer a measure of protection against development of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis), ankylosing spondylitis, rheumatoid arthritis, psoriasis, thyroiditis, recurrent spontaneous abortion and asthma, suggesting that a perturbation in the IL-23 signaling pathway is likely to be relevant to the pathophysiology of these diseases. 27043356

2016

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE After Bonferroni correction for multiple testing, both the homozygous and the heterozygous variant genotypes of IL23R G>A(rs11209026) (OR(CD,adj): 0.38, 95% CI: 0.21-0.67, p = 0.03; OR(IBD,adj) 0.43, 95% CI: 0.28-0.67, p = 0.007) and PTPN22 1858 G>A(rs2476601) (OR(CD,unadj) 0.54, 95% CI: 0.41-0.72, p = 7*10-4; OR(IBD,unadj): 0.61, 95% CI: 0.48-0.77, p = 0.001) were associated with reduced risk of CD. 24971461

2014

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE We observed the association between Crohn's disease and NOD2 (rs17313265, 0.28 in CD, 0.19 in controls, OR 1.5, p = 9×10-6) and IL23R (rs11209026, 0.026 in CD, 0.0.071 in controls, OR 0.4, p = 3.8×10-4). 25259511

2014

dbSNP: rs11209026
rs11209026
G 0.900 GeneticVariation GWASDB A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. 22936669

2013

dbSNP: rs11209026
rs11209026
G 0.900 GeneticVariation GWASCAT A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. 22936669

2013

dbSNP: rs11209026
rs11209026
G 0.900 GeneticVariation GWASDB A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. 22412388

2012

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation GWASDB One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2. 22293688

2012

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2. 22293688

2012

dbSNP: rs11209026
rs11209026
G 0.900 GeneticVariation GWASCAT A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. 22412388

2012

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation GWASCAT One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2. 22293688

2012

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE This data provides an explanation for the protective role of R381Q in CD and may lead to the development of improved therapeutics for autoimmune disorders like CD. 22022372

2011

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880). 20082483

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15; rs2241880 A/G of ATG16L1, and rs11209026 (R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals. 20380008

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Our study provides additional support for the strong protection of the rs11209026 (p.Arg381Gln) variant against paediatric CD. 20192940

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE The rare Q allele of IL23R rs11209026 polymorphism was underrepresented in both paediatric and adult CD cases (P = 0.0018 and P = 0.04, respectively) and no difference was observed between the childhood and the adult cohort. 20380008

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Our meta-analysis supports that two polymorphisms (Arg381Gln and rs7517847) within the IL-23R gene may be considered to be protective factors against developing CD. 20157760

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE The results suggest that IL23R R381Q confers protection against CD and that L310P confers protection against UC in females. 19294505

2010

dbSNP: rs11209026
rs11209026
G 0.900 GeneticVariation GWASDB Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463

2010

dbSNP: rs11209026
rs11209026
G 0.900 GeneticVariation GWASCAT Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880). 20082483

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE An association of variants in the genes encoding the interleukin 23 receptor (IL23R, p.Arg381Gln, rs11209026), and the autophagy-related gene 16-like 1 (ATG16L1, p.Ala197Thr, rs2241880) with Crohn disease (CD) was identified by whole genome association studies, and subsequently confirmed by other works. 19590455

2009