rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
All the genetic models of rs11209026 polymorphism significantly decrease CD and UC risk (except for the recessive model in UC) (p < 0.05).
|
31728561 |
2020 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Specifically the G149R, V362I, and R381Q IL23Rα chain variants are linked to protection against the development of Crohn disease and ulcerative colitis in humans.
|
26887945 |
2016 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
NOD2 p.L1007insC was associated with OFG+CD (P = 0.023) and IL23R p.R381Q with all OFG (P = 0.031).
|
27306066 |
2016 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Finally, rs8074524 and rs10758669 in Crohn's disease and rs11209026 in ulcerative colitis were associated with disease-related operation.
|
27852544 |
2016 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interestingly, a functional single nucleotide polymorphism (SNP) in the IL-23 receptor gene (IL-23R; rs11209026, 1142 G wild-type A reduced function, Arg381Gln, R381Q) seems to confer a measure of protection against development of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis), ankylosing spondylitis, rheumatoid arthritis, psoriasis, thyroiditis, recurrent spontaneous abortion and asthma, suggesting that a perturbation in the IL-23 signaling pathway is likely to be relevant to the pathophysiology of these diseases.
|
27043356 |
2016 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After Bonferroni correction for multiple testing, both the homozygous and the heterozygous variant genotypes of IL23R G>A(rs11209026) (OR(CD,adj): 0.38, 95% CI: 0.21-0.67, p = 0.03; OR(IBD,adj) 0.43, 95% CI: 0.28-0.67, p = 0.007) and PTPN22 1858 G>A(rs2476601) (OR(CD,unadj) 0.54, 95% CI: 0.41-0.72, p = 7*10-4; OR(IBD,unadj): 0.61, 95% CI: 0.48-0.77, p = 0.001) were associated with reduced risk of CD.
|
24971461 |
2014 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed the association between Crohn's disease and NOD2 (rs17313265, 0.28 in CD, 0.19 in controls, OR 1.5, p = 9×10-6) and IL23R (rs11209026, 0.026 in CD, 0.0.071 in controls, OR 0.4, p = 3.8×10-4).
|
25259511 |
2014 |
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
|
22936669 |
2013 |
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
|
22936669 |
2013 |
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
|
22412388 |
2012 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
GWASDB |
One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2.
|
22293688 |
2012 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2.
|
22293688 |
2012 |
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
|
22412388 |
2012 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2.
|
22293688 |
2012 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This data provides an explanation for the protective role of R381Q in CD and may lead to the development of improved therapeutics for autoimmune disorders like CD.
|
22022372 |
2011 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).
|
20082483 |
2010 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15; rs2241880 A/G of ATG16L1, and rs11209026 (R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals.
|
20380008 |
2010 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study provides additional support for the strong protection of the rs11209026 (p.Arg381Gln) variant against paediatric CD.
|
20192940 |
2010 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rare Q allele of IL23R rs11209026 polymorphism was underrepresented in both paediatric and adult CD cases (P = 0.0018 and P = 0.04, respectively) and no difference was observed between the childhood and the adult cohort.
|
20380008 |
2010 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our meta-analysis supports that two polymorphisms (Arg381Gln and rs7517847) within the IL-23R gene may be considered to be protective factors against developing CD.
|
20157760 |
2010 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results suggest that IL23R R381Q confers protection against CD and that L310P confers protection against UC in females.
|
19294505 |
2010 |
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).
|
20082483 |
2010 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
An association of variants in the genes encoding the interleukin 23 receptor (IL23R, p.Arg381Gln, rs11209026), and the autophagy-related gene 16-like 1 (ATG16L1, p.Ala197Thr, rs2241880) with Crohn disease (CD) was identified by whole genome association studies, and subsequently confirmed by other works.
|
19590455 |
2009 |