|
rs13361189
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Our study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings.
|
26066377 |
2015 |
|
rs13361189
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Our meta-analysis results indicate that the IRGM rs13361189 polymorphism contributes to the susceptibility to CD.
|
25526194 |
2014 |
|
rs13361189
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The analysis showed modest significant association for the rs13361189, rs4958847 and rs10065172 variants in Crohn's disease (CD): the risk estimates for the allele contrast were OR=1.306 (1.200-1.420), p=5.2 × 10(-10), OR=1.182 (1.082-1.290), p=0.0002, and OR=1.248 (1.057-1.473), p=0.009 respectively (still significant when the p value was Bonferroni adjusted to 0.017).
|
24232856 |
2013 |
|
rs13361189
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In addition, our meta-analysis data showed that IRGM rs13361189 and rs4958847 polymorphisms were associated with CD (rs13361189 C allele P=1.07 x 10(-19), pooled OR=1.34; rs4958847 A allele P=2.78 x 10(-17), pooled OR=1.31) and UC (rs13361189 P=0.0069, pooled OR=1.16; rs4958847 P=0.014, pooled OR=1.13).
|
19491842 |
2009 |
|
rs13361189
|
|
|
0.850 |
GeneticVariation |
BEFREE |
NCF4 and IRGM were significantly associated with ileal CD (P-value(rs4821544)=0.0090, odds ratio (OR)=1.425, 95% confidence interval (CI): 1.092-1.859; P-value(rs13361189)=0.0017, OR=1.942, 95% CI: 1.274-2.959; P-value(rs4958847)=0.0022, OR=1.767, 95% CI: 1.224-2.558), but not with other forms of inflammatory bowel disease (IBD).
|
18580884 |
2008 |
|
rs13361189
|
|
|
0.850 |
GeneticVariation |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs13361189
|
|
|
0.850 |
GeneticVariation |
GWASCAT |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |
|
rs13361189
|
|
|
0.850 |
GeneticVariation |
GWASDB |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |