Under recessive genetic model (C/C vs. T/T+T/C), the TNF rs1799964 C/C genotype was significantly associated with DEN [P=0.014, OR with 95% CI 3.07 (1.18-7.98)].
The frequency of rs1799964 'C/C' genotype of the TNF gene was found to be significantly higher in all patient groups compared to HCs [HCs vs. DEN, P=0.0054, Pc=0.0162, OR 3.57; HCs vs. DF, P=0.036, OR 2.89; HCs vs. DHF, P=0.0088, Pc=0.0240, OR 5.11].