Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. rTMS treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-HTTLPR LL homozygotes compared to S allele carriers (p=0.007) and in BDNF Val/Val homozygotes compared to Met allele carriers (p=0.024). 18450378

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression. 27073970

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE No differences in whole blood BDNF was seen in relation to the BDNF Val66Met polymorphism and no significant correlations between whole blood BDNF and HAMD-17 or BDI 21 scores were found. 23684538

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression. 18263664

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression. 22931410

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression. 24745471

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF Val66Met genotype and 6-month remission rates in late-life depression. 20195291

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025). 20515362

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects. 23968401

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history. 23880378

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained. 17482146

2007

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity. 20346518

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression. 23303061

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression. 25648279

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression. 20728877

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression. 26462036

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE This study was to examine the chronic stress × BDNF Val66Met</span> interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet. 29734099

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism may modify the association between stroke and depression. 17222482

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The results suggest that the BDNF Val66Met polymorphism is a relevant risk factor for geriatric depression. 16343697

2006

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects. 21577214

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study. 26976307

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels. 22883353

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders. 20515664

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The low activity variants of the 5-HTT-linked polymorphic region in the serotonin transporter gene and the Met-allele of a single nucleotide polymorphism (Val66Met) in the gene encoding brain derived neurotrophic factor were independently associated with the presence of stressful life events prior to onset of depression, also when corrected for the effect of age, gender, marital status, personality disorder, neuroticism, and severity of depressive symptoms at the time of interview. 19339052

2009