Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies. 20667416

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. 21420735

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents. 21037213

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF Val66Met genotype and 6-month remission rates in late-life depression. 20195291

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression. 20728877

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism. 21143020

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity. 20346518

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Furthermore, the sex-specific genotype effects may contribute to sex-specific effects of BDNF Val66Met on depression vulnerability. 20097294

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE In the total sample, the BDNF Val66Met polymorphism was not significantly associated with depression. 18852698

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. 19335934

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The low activity variants of the 5-HTT-linked polymorphic region in the serotonin transporter gene and the Met-allele of a single nucleotide polymorphism (Val66Met) in the gene encoding brain derived neurotrophic factor were independently associated with the presence of stressful life events prior to onset of depression, also when corrected for the effect of age, gender, marital status, personality disorder, neuroticism, and severity of depressive symptoms at the time of interview. 19339052

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression. 20220593

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders. 20515664

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits. 20345896

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity. 18721847

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. 19153574

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression. 18179845

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Here, we determined the effects of the BDNF Val66met polymorphism on the five-factor personality dimensions (assessed using the NEO-FFI), trait depression (assessed with the DASS-21) in a cross-sectional cohort of 467 healthy volunteers. 18548532

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes. 18205169

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research. 17700574

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression. 18263664

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism may modify the association between stroke and depression. 17222482

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression. 17911362

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE 5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing. 18347599

2008