|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aims of the present case-control study were to investigate the possible role of BDNF Val66Met, 5-HTTLPR and -1438 G/A polymorphisms in the development of coronary artery disease (CAD) in patients with and without depression.
|
19885623 |
2009 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression.
|
17959306 |
2007 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies.
|
20667416 |
2011 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
|
27335045 |
2017 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.
|
21037213 |
2010 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms.
|
27852165 |
2017 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes.
|
18205169 |
2008 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF.
|
29280414 |
2019 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population.
|
29535036 |
2019 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, the association between DED and Val66Met may vary by depression status.
|
26393465 |
2015 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety.
|
25618300 |
2015 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we determined the effects of the BDNF Val66met polymorphism on the five-factor personality dimensions (assessed using the NEO-FFI), trait depression (assessed with the DASS-21) in a cross-sectional cohort of 467 healthy volunteers.
|
18548532 |
2009 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC.
|
30904785 |
2019 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models.
|
26795846 |
2016 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect.
|
29102837 |
2018 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke.
|
23399480 |
2013 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study.
|
23481907 |
2013 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder.
|
15913870 |
2005 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects.
|
14673216 |
2003 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.
|
19335934 |
2009 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the A allele of rs6265 (Val66Met) was significantly higher in AD-D patients than in the healthy controls (p=0.009 after Bonferroni correction).
|
21880305 |
2011 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms might predict the incidence of depression with ABB.
|
24274373 |
2013 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.
|
25745134 |
2015 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |