rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no interaction between depression and Val66Met genotype status.
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25188405 |
2014 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No differences in whole blood BDNF was seen in relation to the BDNF Val66Met polymorphism and no significant correlations between whole blood BDNF and HAMD-17 or BDI 21 scores were found.
|
23684538 |
2013 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects.
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23968401 |
2013 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history.
|
23880378 |
2013 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression.
|
23303061 |
2013 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke.
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23399480 |
2013 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study.
|
23481907 |
2013 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms might predict the incidence of depression with ABB.
|
24274373 |
2013 |
rs759834365
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|
0.100 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.
|
22931410 |
2012 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects.
|
21577214 |
2012 |
rs759834365
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|
|
0.100 |
GeneticVariation |
BEFREE |
Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels.
|
22883353 |
2012 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression.
|
22033217 |
2012 |
rs759834365
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|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls.
|
22610920 |
2012 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF Val66Met genotype and 6-month remission rates in late-life depression.
|
20195291 |
2011 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies.
|
20667416 |
2011 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the A allele of rs6265 (Val66Met) was significantly higher in AD-D patients than in the healthy controls (p=0.009 after Bonferroni correction).
|
21880305 |
2011 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD).
|
21692988 |
2011 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity.
|
20346518 |
2010 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression.
|
20728877 |
2010 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders.
|
20515664 |
2010 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.
|
21037213 |
2010 |