DisGeNET - a database of gene-disease associations

Mental Depression, C0011570

Variant: rs41423247 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs41423247

NR3C1

0.030

GeneticVariation

BEFREE

This meta-analysis demonstrates that the NR3C1 rs41423247 homozygous mutation may be a risk factor for depression.

30278546

2018

dbSNP:

rs41423247

NR3C1

0.030

GeneticVariation

BEFREE

Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.

27428087

2016

dbSNP:

rs41423247

NR3C1

0.030

GeneticVariation

BEFREE

In a sample of 800 healthy participants, we genotyped for the BCL1 rs41423247 and the CHRNA4 rs1044396 single-nucleotide polymorphisms and assessed depressiveness by means of the Beck Depression Inventory.

22760121

2012