Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. 30329132

2020

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF. 29280414

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population. 29535036

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT. 29802070

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC. 30904785

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect. 29102837

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression. 29331787

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE This study was to examine the chronic stress × BDNF Val66Met interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet. 29734099

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression. 27073970

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression. 27335045

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The present findings indicate the gender differences in the effect of Val66Met genotype on the cortisol responses to stress protocol, and extend the evidence for the importance of gender and the role of Val66Met in the modulation of stress reactivity and subsequent depression prevalence. 28249185

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence depression. 28527683

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression. 26756166

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models. 26795846

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study. 26976307

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety. 25618300

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression. 25648279

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression. 25745134

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression. 26000753

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Additionally, the association between DED and Val66Met may vary by depression status. 26393465

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression. 26462036

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03). 24433458

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression. 24745471

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE There was no interaction between depression and Val66Met genotype status. 25188405

2014