DisGeNET - a database of gene-disease associations

Depressive disorder, C0011581

Variant: rs1217691063 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

Present meta-analysis supports that there is a meager significant association between MTHFR C677T polymorphism and depression risk.

28968218

2017

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

Overall, T variant of MTHFR C677T gene polymorphism was significantly associated with an increased risk of depression in the Chinese population (T vs. C: OR = 1.52, 95% CI = 1.24-1.85; TT + CT vs. CC: OR = 1.64, 95% CI = 1.16-2.30; TT vs. CC: OR = 2.19, 95% CI = 1.49-3.24; TT vs. CC + CT: OR = 1.80, 95% CI = 1.31-2.46).

26681493

2016

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.

24532086

2014

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

In conclusion results of present meta-analysis supports that there is a significant association between MTHFR C677T polymorphism and depression risk, and MTHFR 677T allele contributes to increased risk of depression in Asian individuals.

26177556

2014

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression.

23900311

2013

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.

23116396

2013

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

No statistically significant difference was observed when global DNA methylation were stratified according to C677T MTHFR genotypes (p = 0.7200), BMI (p = 0.1170), smoking habit (p = 0.4382), physical activity in daily life (p = 0.8492), scored cognitive function (p = 0.7229) or depression state (p = 0.8301).

23285094

2012

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

Low folate is unlikely to be an important risk factor for depression during pregnancy and for postpartum depression, but may be a risk factor for depression outside of pregnancy, especially among women with the MTHFR C677T TT genotype.

21772318

2012

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression.

22739363

2012

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

Our findings suggest that MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.

22668858

2012

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

MTHFR C677T is associated with MA in individuals selected for depression study.

21635773

2011

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

In addition, the C677T-MTHFR association adds further support to existing findings underscoring the potential role of folate in depression.

21125200

2010

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high frequencies of potential risk alleles.

19251870

2009

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

We found a significant contribution of the MTHFR 677C>T polymorphic variants to depression in postmenopausal women.

18801628

2008

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention.

17074966

2007

dbSNP:

rs1217691063

MTHFR

0.100

GeneticVariation

BEFREE

Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.

12796225

2003

dbSNP: