|
rs2230912
|
|
|
0.070 |
GeneticVariation |
BEFREE |
However, dimensional analyses showed significant associations of the HADS depression severity scores with Gln460Arg (rs2230912) and Ala348Thr (rs1718119) in the depressed and diabetic patient groups.
|
30664971 |
2019 |
|
rs2230912
|
|
|
0.070 |
GeneticVariation |
BEFREE |
However, dimensional analyses showed significant associations of the HADS depression severity scores with Gln460Arg (rs2230912) and Ala348Thr (rs1718119) in the depressed and diabetic patient groups.
|
30664971 |
2019 |
|
rs2230912
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The P2RX7 polymorphism rs2230912 is associated with depression: A meta-analysis.
|
29122639 |
2018 |
|
rs2230912
|
|
|
0.070 |
GeneticVariation |
BEFREE |
These results indicate that heterozygosity for the wild-type P2X7R and its mood disorder-associated variant P2X7R-Gln460Arg represents a genetic risk factor, which is potentially able to convey susceptibility to mood disorders.<b>SIGNIFICANCE STATEMENT</b> Depression and bipolar disorder are the most common mood disorders.
|
29079688 |
2017 |
|
rs2230912
|
|
|
0.070 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs2230912
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology.
|
20226536 |
2010 |
|
rs2230912
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In conclusion, case-control analysis did not reveal significant results, but using a symptom severity scale we could support the association between depressive disorder and the G-allele of the Gln460Arg polymorphism in the P2RX7 gene.
|
18543274 |
2009 |
|
rs2230912
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our results support the role of the P2RX7 rs2230912 G-allele in the development of depression and emphasize the importance of good glycemic control, acting as a potential protective factor in diabetic patients.
|
18801407 |
2008 |