|
rs4994
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A tryptophan to arginine (Trp64Arg) mutation in the beta 3-adrenergic receptor (beta 3-AR) gene has been implicated in diabetes and obesity.
|
8826971 |
1996 |
|
rs1444739794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The V62A mutation, which has not been previously reported, cosegregated with diabetes in the N2 family.
|
9736233 |
1998 |
|
rs1267969615
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Relative nocturnal systolic and diastolic pressures in patients with diabetes were higher than in healthy age- and height-matched controls; no association was found with the angiotensinogen gene M235T polymorphism.
|
9950302 |
1999 |
|
rs699
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Relative nocturnal systolic and diastolic pressures in patients with diabetes were higher than in healthy age- and height-matched controls; no association was found with the angiotensinogen gene M235T polymorphism.
|
9950302 |
1999 |
|
rs1267969615
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We examined angiotensin-converting enzyme (ACE) DD/II and angiotensinogen (Atg) M235T polymorphism in a cohort of Chinese patients with type II diabetes with an average duration of diabetes of 14 years.
|
10352194 |
1999 |
|
rs699
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We examined angiotensin-converting enzyme (ACE) DD/II and angiotensinogen (Atg) M235T polymorphism in a cohort of Chinese patients with type II diabetes with an average duration of diabetes of 14 years.
|
10352194 |
1999 |
|
rs28936379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Localisation of presenilin 2 in human and rodent pancreatic islet beta-cells; Met239Val presenilin 2 variant is not associated with diabetes in man.
|
10362543 |
1999 |
|
rs1800566
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
|
10447260 |
1999 |
|
rs1258159645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
|
10447260 |
1999 |
|
rs1801278
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The allele frequencies of the Gly972Arg variant of the insulin receptor substrate-1 (IRS-1) gene and the Ala54Thr variant of the fatty acid binding protein 2 (FABP2) gene were compared in 992 normal control subjects and three patient groups: 1) 321 type 2 diabetic individuals, 2) 260 severely obese individuals, and 3) 258 markedly hyperinsulinemic individuals without diabetes.
|
10480621 |
1999 |
|
rs1799883
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The allele frequencies of the Gly972Arg variant of the insulin receptor substrate-1 (IRS-1) gene and the Ala54Thr variant of the fatty acid binding protein 2 (FABP2) gene were compared in 992 normal control subjects and three patient groups: 1) 321 type 2 diabetic individuals, 2) 260 severely obese individuals, and 3) 258 markedly hyperinsulinemic individuals without diabetes.
|
10480621 |
1999 |
|
rs137852783
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The lower penetrance D76N and Q59L mutations were more prevalent and were associated with a relative risk of 12.6 for diabetes and with decreased glucose-stimulated insulin-secretion in nondiabetic subjects.
|
10545531 |
1999 |
|
rs137852784
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The lower penetrance D76N and Q59L mutations were more prevalent and were associated with a relative risk of 12.6 for diabetes and with decreased glucose-stimulated insulin-secretion in nondiabetic subjects.
|
10545531 |
1999 |
|
rs1169305
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes.
|
10690959 |
2000 |
|
rs1406167595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes.
|
10690959 |
2000 |
|
rs142318174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes.
|
10690959 |
2000 |
|
rs587778393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes.
|
10690959 |
2000 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One of the 220 patients (0.45%) with diabetes was homozygous for the HFE 845A (C282Y) mutation and 25 (11.3%) were heterozygous for the same mutation, of whom 3 (1.3%) were compound heterozygotes also carrying the HFE 187G (H63D) mutation.
|
10695662 |
2000 |
|
rs1799945
|
|
|
0.070 |
GeneticVariation |
BEFREE |
One of the 220 patients (0.45%) with diabetes was homozygous for the HFE 845A (C282Y) mutation and 25 (11.3%) were heterozygous for the same mutation, of whom 3 (1.3%) were compound heterozygotes also carrying the HFE 187G (H63D) mutation.
|
10695662 |
2000 |
|
rs137852783
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Neither the D76N nor the A140T segregated with diabetes, and their transcriptional activation of the human insulin promoter expressed in vitro was indistinguishable from that of the wild type (115 +/- 21% and 84 +/- 12% vs. 100%).
|
10720084 |
2000 |
|
rs1240512008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither the D76N nor the A140T segregated with diabetes, and their transcriptional activation of the human insulin promoter expressed in vitro was indistinguishable from that of the wild type (115 +/- 21% and 84 +/- 12% vs. 100%).
|
10720084 |
2000 |
|
rs143517122
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither the D76N nor the A140T segregated with diabetes, and their transcriptional activation of the human insulin promoter expressed in vitro was indistinguishable from that of the wild type (115 +/- 21% and 84 +/- 12% vs. 100%).
|
10720084 |
2000 |
|
rs754907741
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither the D76N nor the A140T segregated with diabetes, and their transcriptional activation of the human insulin promoter expressed in vitro was indistinguishable from that of the wild type (115 +/- 21% and 84 +/- 12% vs. 100%).
|
10720084 |
2000 |
|
rs763010207
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither the D76N nor the A140T segregated with diabetes, and their transcriptional activation of the human insulin promoter expressed in vitro was indistinguishable from that of the wild type (115 +/- 21% and 84 +/- 12% vs. 100%).
|
10720084 |
2000 |
|
rs779271027
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither the D76N nor the A140T segregated with diabetes, and their transcriptional activation of the human insulin promoter expressed in vitro was indistinguishable from that of the wild type (115 +/- 21% and 84 +/- 12% vs. 100%).
|
10720084 |
2000 |