|
rs4994
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A tryptophan to arginine (Trp64Arg) mutation in the beta 3-adrenergic receptor (beta 3-AR) gene has been implicated in diabetes and obesity.
|
8826971 |
1996 |
|
rs1444739794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The V62A mutation, which has not been previously reported, cosegregated with diabetes in the N2 family.
|
9736233 |
1998 |
|
rs1267969615
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Relative nocturnal systolic and diastolic pressures in patients with diabetes were higher than in healthy age- and height-matched controls; no association was found with the angiotensinogen gene M235T polymorphism.
|
9950302 |
1999 |
|
rs1267969615
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We examined angiotensin-converting enzyme (ACE) DD/II and angiotensinogen (Atg) M235T polymorphism in a cohort of Chinese patients with type II diabetes with an average duration of diabetes of 14 years.
|
10352194 |
1999 |
|
rs699
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We examined angiotensin-converting enzyme (ACE) DD/II and angiotensinogen (Atg) M235T polymorphism in a cohort of Chinese patients with type II diabetes with an average duration of diabetes of 14 years.
|
10352194 |
1999 |
|
rs699
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Relative nocturnal systolic and diastolic pressures in patients with diabetes were higher than in healthy age- and height-matched controls; no association was found with the angiotensinogen gene M235T polymorphism.
|
9950302 |
1999 |
|
rs1801278
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The allele frequencies of the Gly972Arg variant of the insulin receptor substrate-1 (IRS-1) gene and the Ala54Thr variant of the fatty acid binding protein 2 (FABP2) gene were compared in 992 normal control subjects and three patient groups: 1) 321 type 2 diabetic individuals, 2) 260 severely obese individuals, and 3) 258 markedly hyperinsulinemic individuals without diabetes.
|
10480621 |
1999 |
|
rs137852783
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The lower penetrance D76N and Q59L mutations were more prevalent and were associated with a relative risk of 12.6 for diabetes and with decreased glucose-stimulated insulin-secretion in nondiabetic subjects.
|
10545531 |
1999 |
|
rs1799883
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The allele frequencies of the Gly972Arg variant of the insulin receptor substrate-1 (IRS-1) gene and the Ala54Thr variant of the fatty acid binding protein 2 (FABP2) gene were compared in 992 normal control subjects and three patient groups: 1) 321 type 2 diabetic individuals, 2) 260 severely obese individuals, and 3) 258 markedly hyperinsulinemic individuals without diabetes.
|
10480621 |
1999 |
|
rs137852784
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The lower penetrance D76N and Q59L mutations were more prevalent and were associated with a relative risk of 12.6 for diabetes and with decreased glucose-stimulated insulin-secretion in nondiabetic subjects.
|
10545531 |
1999 |
|
rs1800566
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
|
10447260 |
1999 |
|
rs1258159645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
|
10447260 |
1999 |
|
rs2229616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that mutations including V103I in the MC4R gene are not a major cause of obesity or diabetes in Japanese.
|
11246450 |
1999 |
|
rs28936379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Localisation of presenilin 2 in human and rodent pancreatic islet beta-cells; Met239Val presenilin 2 variant is not associated with diabetes in man.
|
10362543 |
1999 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One of the 220 patients (0.45%) with diabetes was homozygous for the HFE 845A (C282Y) mutation and 25 (11.3%) were heterozygous for the same mutation, of whom 3 (1.3%) were compound heterozygotes also carrying the HFE 187G (H63D) mutation.
|
10695662 |
2000 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
rs137853240
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Despite the failure of linkage analysis to identify HNF1A as a determinant of type 2 diabetes, we feel justified in interpreting that G319S has a very important pathogenic role in Oji-Cree diabetes, based upon the highly suggestive association studies.
|
10807546 |
2000 |
|
rs1799945
|
|
|
0.070 |
GeneticVariation |
BEFREE |
One of the 220 patients (0.45%) with diabetes was homozygous for the HFE 845A (C282Y) mutation and 25 (11.3%) were heterozygous for the same mutation, of whom 3 (1.3%) were compound heterozygotes also carrying the HFE 187G (H63D) mutation.
|
10695662 |
2000 |
|
rs137852783
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Neither the D76N nor the A140T segregated with diabetes, and their transcriptional activation of the human insulin promoter expressed in vitro was indistinguishable from that of the wild type (115 +/- 21% and 84 +/- 12% vs. 100%).
|
10720084 |
2000 |
|
rs137852783
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We did not detect the D76N variant, which was the most frequent variant in subjects with a strong family history of diabetes, in patients or controls.
|
11022198 |
2000 |
|
rs137852785
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Three variants (C18R, Q59L and D76N) were screened by PCR-RFLP in a group of 296 unrelated French late-onset type 2 diabetic subjects consecutively recruited in a diabetes department of a university hospital, regardless of family history of diabetes.
|
11022198 |
2000 |
|
rs11575937
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We previously identified a novel mutation, namely LMNA R482Q, that was found to underlie Dunnigan-type partial lipodystrophy (FPLD) and diabetes in an extended Canadian kindred.
|
10999845 |
2000 |
|
rs1169305
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes.
|
10690959 |
2000 |
|
rs137852784
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Three variants (C18R, Q59L and D76N) were screened by PCR-RFLP in a group of 296 unrelated French late-onset type 2 diabetic subjects consecutively recruited in a diabetes department of a university hospital, regardless of family history of diabetes.
|
11022198 |
2000 |