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rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We recruited 189 patients with T2D being treated with SUs and determined the rs7903146 diabetes risk genotype.
|
21349175 |
2011 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TT genotype of rs7903146 was also significantly associated with higher fasting plasma insulin level and the homeostasis model assessment of insulin resistance in case of new-onset diabetes.
|
27998387 |
2016 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02).
|
22461567 |
2012 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In subjects without known diabetes (n=961) recruited from the Chennai Urban Rural Epidemiology Study (CURES), OGTT, IDRS, and genotyping of rs12255372 (G/T) and rs7903146(C/T) of TCF7L2 polymorphisms were done.
|
21441683 |
2011 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Diabetes disease stage was marginally significantly associated with the frequency of the T variant at rs12255372 (p=0.057; adjusted p=0.017) but not at rs7903146 (p=0.5; adjusted p=0.2).
|
18282631 |
2008 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.
|
20980453 |
2011 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for traditional diabetes risk factors (diabetes in family, waist circumference, physical activity, BMI, SBP and total and HDL-cholesterol) in both a cross-sectional and prospective setting (cross-sectional: rs12255372 OR 1.61 (1.31-1.99), rs7903146 OR 1.48 (1.20-1.83) and prospective: rs12255372 OR 1.59 (1.22-2.07), rs7903146 OR 1.47 (1.11-1.93)).
|
18972257 |
2009 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A variant in TCF7L2 associated with type 2 diabetes (the T allele at rs7903146) was associated with diabetes in CF in the family study (p = 0.004) and in the case-control study (p = 0.02; combined p = 0.0002).
|
19585101 |
2009 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903146) for diabetes.
|
18268068 |
2008 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined as fasting serum glucose levels of 100-125 mg/dL (5.6-6.9 mmol/L) in 1377 African American and 5152 Caucasian participants without diabetes and IFG at intake who participated in the Atherosclerosis Risk in Communities (ARIC) Study from 1987 to 1989 and were followed for 9 years.
|
20578204 |
2010 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs7903146 T allele is associated with diabetes and, in non-diabetic individuals, with a higher prevalence and severity of coronary artery disease and cardiovascular events. name of registry site (see list below), registration number, trial registration URL in brackets.
|
19924244 |
2009 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated.
|
28299838 |
2017 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.
|
26914832 |
2016 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study revealed no differences in the kinetics of glucose, insulin, C-peptide and non-esterified fatty acids during an OGTT in homozygous participants from a German diabetes risk cohort (n = 1832) carrying either the rs7903146 CC (n = 15) or the TT (n = 15) genotype.
|
24925104 |
2014 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk in a Brazilian population and to assess the use of this genetic marker in improving diabetes risk prediction in the general population.
|
19055834 |
2008 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TCF7L2 rs7903146 T-allele was associated with type 2 diabetes (hazard ratio=1.51</span>; 95 % CI 1.21, 1.87) and modified the inverse association between whole-grain intake and diabetes risk (P=0.016 for interaction).
|
19149908 |
2009 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM.
|
25185853 |
2014 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with lower estimated GFR (P = 0.01) and higher cystatin C (P = 0.004) in adjusted analyses overall and among those without diabetes.
|
18650481 |
2008 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There is a trend toward an association between faster GE and the diabetes-associated allele at rs7903146 in TCF7L2.
|
31691451 |
2020 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Over an average period of three years, participants with the risk-conferring TT genotype at rs7903146 were more likely to have progression from impaired glucose tolerance to diabetes than were CC homozygotes (hazard ratio, 1.55; 95 percent confidence interval, 1.20 to 2.01; P<0.001).
|
16855264 |
2006 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes risk in a large African American population and also demonstrates that the diabetes risk conveyed by the rs7903146 risk allele is substantially increased in the context of some metabolic risk factors for type 2 diabetes.
|
18931037 |
2009 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the T allele (conferring higher risk of diabetes) at rs7903146 was associated with higher fasting proinsulin at baseline (P<0.001), higher baseline proinsulin:insulin ratio (p<0.0001) and increased proinsulin:insulin ratio over a median of 2.5 years of follow-up (P = 0.003).
|
21814547 |
2011 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes incidence in the DESIR cohort.
|
17977958 |
2008 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The minor allele frequency for rs7903146 was different between TCP and FCPD patients carrying the N34S SPINK1 variant but did not reach statistical significance (OR = 1.59, 95% CI = 0.93-2.70, P = 0.09), while, TCF7L2variant showed a statistically significant association between TCP and FCPD patients carrying the 26V allele (OR = 1.69, 95% CI = 1.11-2.56, P = 0.013).
|
18706099 |
2008 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For four candidate SNPs (rs780094, rs10830963, rs7903146, and rs4607517), the strength of association between genotype and glucose was significantly (P-interaction<0.05) different in those with and without prevalent diabetes, and for all five fasting glucose candidate SNPs (rs780094, rs10830963, rs560887, rs4607517, and rs13266634) the association with measured fasting glucose was more significant in the smaller sample without prevalent diabetes than in the larger combined sample of those with and without diabetes.
|
20839289 |
2010 |