Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7903146
rs7903146
TCF7L2
0.100 GeneticVariation BEFREE rs7903146 T allele is associated with diabetes and, in non-diabetic individuals, with a higher prevalence and severity of coronary artery disease and cardiovascular events. name of registry site (see list below), registration number, trial registration URL in brackets. 19924244

2009
dbSNP: rs228648
rs228648
UTS2
0.010 GeneticVariation BEFREE Thr21Met (T21M) and Ser89Asn (S89N) polymorphisms of the UTS2 gene were associated with the risk of developing diabetes and DR. M21M genotype frequencies were high in PDR (8.9% in diabetic control vs. 54.6% in PDR, P = 0.0092) group. 22587369

2012
dbSNP: rs1406167595
rs1406167595
TCF7
0.010 GeneticVariation BEFREE A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes. 10690959

2000
dbSNP: rs142318174
rs142318174
HNF1A ; HNF1A-AS1
0.010 GeneticVariation BEFREE A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes. 10690959

2000
dbSNP: rs587778393
rs587778393
HNF1A ; HNF1A-AS1
0.010 GeneticVariation BEFREE A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes. 10690959

2000
dbSNP: rs1169305
rs1169305
HNF1A
0.020 GeneticVariation BEFREE A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes. 10690959

2000
dbSNP: rs142727972
rs142727972
EHMT1
0.010 GeneticVariation BEFREE A c.839C>T (p.(Thr280Met)) variant (rs200998587:C>T, risk allele frequency = 0.03) in RBPJL, identified only in Amerindian-derived populations, associated with T2D (OR = 1.60[1.21-2.13] per Met allele, P = 0.001) and age of diabetes onset (HR = 1.40[1.14-1.72], P = 0.001). 29302047

2018
dbSNP: rs200998587
rs200998587
RBPJL
0.010 GeneticVariation BEFREE A c.839C>T (p.(Thr280Met)) variant (rs200998587:C>T, risk allele frequency = 0.03) in RBPJL, identified only in Amerindian-derived populations, associated with T2D (OR = 1.60[1.21-2.13] per Met allele, P = 0.001) and age of diabetes onset (HR = 1.40[1.14-1.72], P = 0.001). 29302047

2018
dbSNP: rs1308346790
rs1308346790
RBPJ
0.010 GeneticVariation BEFREE A c.839C>T (p.(Thr280Met)) variant (rs200998587:C>T, risk allele frequency = 0.03) in RBPJL, identified only in Amerindian-derived populations, associated with T2D (OR = 1.60[1.21-2.13] per Met allele, P = 0.001) and age of diabetes onset (HR = 1.40[1.14-1.72], P = 0.001). 29302047

2018
dbSNP: rs5443
rs5443
GNB3 ; CDCA3
0.020 GeneticVariation BEFREE A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT+TC with an odds ratio of 0.62 (p=0.008) independent of age, gender, and BMI. 18656447

2008
dbSNP: rs137853240
rs137853240
HNF1A
0.090 GeneticVariation BEFREE A combination of abnormal splicing and reduced activity of the G319S protein may explain the diabetes susceptibility. 18586913

2008
dbSNP: rs1801282
rs1801282
PPARG
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 16393309

2006
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 16393309

2006
dbSNP: rs1801282
rs1801282
PPARG
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 17763950

2008
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 17763950

2008
dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE A common variant, rs9939609, in the FTO (fat mass and obesity) gene is associated with adiposity in Europeans, explaining its relationship with diabetes. 21294771

2011
dbSNP: rs3115757
rs3115757
APLN
0.010 GeneticVariation BEFREE A correlation between rs3115757 and rs2281068 and diabetes was observed in first batch. 27831922

2016
dbSNP: rs4607517
rs4607517
GCK
0.020 GeneticVariation BEFREE A genetic variant near the glucokinase gene (rs4607517) was significantly associated with progression to prediabetes or diabetes (hazard ratio 1·27, 1·16-1·38; p=1·70 × 10(-7)). 26577716

2016
dbSNP: rs57922
rs57922 		0.010 GeneticVariation BEFREE A genome-wide association study in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial identified two markers (rs57922 and rs9299870) that were significantly associated with cardiovascular mortality during intensive glycemic control and could potentially be used, when combined into a genetic risk score (GRS), to identify patients with diabetes likely to derive benefit from intensive control rather than harm. 29183908

2018
dbSNP: rs9299870
rs9299870
MGMT
0.010 GeneticVariation BEFREE A genome-wide association study in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial identified two markers (rs57922 and rs9299870) that were significantly associated with cardiovascular mortality during intensive glycemic control and could potentially be used, when combined into a genetic risk score (GRS), to identify patients with diabetes likely to derive benefit from intensive control rather than harm. 29183908

2018
dbSNP: rs13333226
rs13333226
UMOD
0.710 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844

2018
dbSNP: rs10224002
rs10224002
PRKAG2
A 0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844

2018
dbSNP: rs11622435
rs11622435
LOC101928462
0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844

2018
dbSNP: rs11864909
rs11864909
PDILT
T 0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844

2018
dbSNP: rs1974990
rs1974990 		G 0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844

2018