Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28938469
rs28938469
0.010 GeneticVariation BEFREE We explored the gene responsible for diabetes in two brothers, who were suspected to have diabetes at 15 and 18 years-of-age, respectively, with whole exome sequencing, and identified a compound heterozygous ABCC8 gene mutation (p.Arg168Cys and p.Arg1421Cys). 31479591

2020

dbSNP: rs36217263
rs36217263
KL
0.010 GeneticVariation BEFREE The deletion of at least one copy of allele A of rs36217263 near Klotho showed statistically significant association with poor response to beta-blockers (dominant; odds ratio (OR) = 3.89; P = 0.017), adjusted for diabetes and dyslipidemia. 31350855

2020

dbSNP: rs505151
rs505151
0.010 GeneticVariation BEFREE In CAD patients, the AG genotype of PSCK9 rs505151 is associated with diabetes and a positive family history of CAD. 30947598

2020

dbSNP: rs756823374
rs756823374
0.010 GeneticVariation BEFREE We explored the gene responsible for diabetes in two brothers, who were suspected to have diabetes at 15 and 18 years-of-age, respectively, with whole exome sequencing, and identified a compound heterozygous ABCC8 gene mutation (p.Arg168Cys and p.Arg1421Cys). 31479591

2020

dbSNP: rs8133052
rs8133052
0.010 GeneticVariation BEFREE Regarding the docetaxel phase, high levels of abdominal pain and mucositis were related to CBR3 gene (rs8133052) polymorphism and diabetes respectively. 31056713

2020

dbSNP: rs1057520291
rs1057520291
0.010 GeneticVariation BEFREE Herein, we present a child who was diagnosed with CHI at birth, then developed diabetes mellitus at the age of nine years due to a novel homozygous missense, p.L171F (c.511C>T) mutation in exon 4 of <i>ABCC8</i>. 29739729

2019

dbSNP: rs1060366
rs1060366
0.010 GeneticVariation BEFREE Thus, allele A of G94A SNP (rs1060366) could be a risk allele for diabetes susceptibility among Egyptian patients. 31523248

2019

dbSNP: rs10757272
rs10757272
0.010 GeneticVariation BEFREE Subjects with rs10757272 were found to have an increased odds ratio (OR) of having severe CAC in multivariate logistic regression analysis after adjusting for age, sex, hypertension, and diabetes (adjusted OR 3.24 and 95% CI 2.11-4.97). 30921371

2019

dbSNP: rs11136000
rs11136000
CLU
0.010 GeneticVariation BEFREE The rs11136000 genotypes in combination with HDL levels and knowledge about diabetes background may be used as a predictive medicine tool for cognitive disorders. 30560405

2019

dbSNP: rs11207997
rs11207997
0.010 GeneticVariation BEFREE Cox proportional hazard models showed that the rs11207997 T allele is associated with a lower risk of DM after adjusting for covariates (hazard ratio: 0.90, 95% confidence interval: 0.812-0.998, p = 0.046). 30683883

2019

dbSNP: rs12513649
rs12513649
0.010 GeneticVariation BEFREE CREBRF rs12513649 and rs373863828 were genotyped in 2022 participants in a community-based cross-sectional study designed to identify determinants of diabetes and end-stage renal disease (ESRD). 31280340

2019

dbSNP: rs184003
rs184003
0.010 GeneticVariation BEFREE The rs184003 SNP seems related to coronary artery disease, breast cancer, and diabetes. 30863465

2019

dbSNP: rs192902098
rs192902098
0.010 GeneticVariation BEFREE In this study, we screened a large cohort of subjects with increased risk for diabetes and identified two subjects with impaired glucose tolerance carrying common, heterozygous, missense mutations in the PDX1 coding region leading to single amino acid exchanges (P33T, C18R) in its transactivation domain. 30930126

2019

dbSNP: rs200879349
rs200879349
0.010 GeneticVariation BEFREE Here we describe a loss-of-function <i>SLC19A2</i> mutation (c.A1063C: p.Lys355Gln) in a family with early-onset diabetes and mild TRMA traits transmitted in an autosomal dominant fashion. 30833467

2019

dbSNP: rs2066853
rs2066853
AHR
0.010 GeneticVariation BEFREE In acromegaly, GSTP1 gene methylation associates with resistance to SSA treatment, especially in patients carrying also the AHR rs2066853 variant, and with increased prevalence of colonic polyps and diabetes mellitus. 30488289

2019

dbSNP: rs2241745
rs2241745
0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165

2019

dbSNP: rs2278426
rs2278426
0.010 GeneticVariation BEFREE Association between rs2278426 (C/T) and rs892066 (C/G) variants of ANGPTL8 (betatrophin) and susceptibility to type2 diabetes mellitus. 30191588

2019

dbSNP: rs370963321
rs370963321
0.010 GeneticVariation BEFREE We discovered three HDAC4 mutations (p.His227Arg, p.Asp234Asn, and p.Glu374Lys) in unrelated individuals who had nonautoimmune diabetes with various degrees of β-cell loss. 30968599

2019

dbSNP: rs372098146
rs372098146
0.010 GeneticVariation BEFREE Here we expressed, in dPdxk<sup>1</sup> mutant flies, four PDXK human variants: three (D87H, V128I and H246Q) listed in databases, and one (A243G) found in a genetic screening in patients with diabetes. 31578392

2019

dbSNP: rs3733197
rs3733197
0.010 GeneticVariation BEFREE This study was the first to demonstrate that a BANK1 gene SNP (rs3733197) could confer genetic predisposition in PM/DM patients and PM/DM patients with ILD in a Chinese Han population. 30145638

2019

dbSNP: rs373863828
rs373863828
0.010 GeneticVariation BEFREE Meta-analyses combining the current results with previous results in Polynesians showed a strong association between the A allele at rs373863828 and BMI (β = 1.38 kg/m<sup>2</sup>; p = 2.5 × 10<sup>-29</sup>) and diabetes (OR 0.65, p = 1.5 × 10<sup>-13</sup>). 31280340

2019

dbSNP: rs3745297
rs3745297
HRC
0.010 GeneticVariation BEFREE The patient age was younger and rate of diabetes and hypertension lower in the PAF patients with Ser96Ala than in those without (TT/TG/GG, 179/120/35; 64±10/60±12/59±13 y, P = 0.001; 18.5/ 9.2/8.6%, P = 0.04 and 66.1/50.0/37.1%, P = 0.001, respectively). 30840693

2019

dbSNP: rs377592729
rs377592729
0.010 GeneticVariation BEFREE Here we expressed, in dPdxk<sup>1</sup> mutant flies, four PDXK human variants: three (D87H, V128I and H246Q) listed in databases, and one (A243G) found in a genetic screening in patients with diabetes. 31578392

2019

dbSNP: rs4376531
rs4376531
0.010 GeneticVariation BEFREE Our data suggested that GC and GG/GC of rs4376531 contributed to a decreased risk of AS while CC genotype, interacting with diabetes, increased the stroke risk in Han Chinese population. 30149742

2019

dbSNP: rs4717806
rs4717806
0.010 GeneticVariation BEFREE Finally, a statistical association of rs4717806(AA) genotype with higher TyG index in IHD patients (P = .03) was highlighted by multiple regression analysis considering log-transformed biochemical parameters as dependent variable and presence of coronary artery disease, age, gender, waist circumference, presence of diabetes as predictors. 31192914

2019