|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The data did suggest that risk of cognitive decline is greater when Pro12A</span>la carriers contract diabetes.
|
18280041 |
2008 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the A allele of P12A polymorphism was 0.16 and the t allele of c1431t polymorphism, 0.13 in patients with type 2 diabetes, and 0.13 and 0.12 respectively in subjects without diabetes 3.2% of patients with and 1.4% without type 2 diabetes were A12A.
|
11409297 |
2001 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genetic influence of PPARG P12A genotype is modest and is overshadowed by duration of diabetes and systolic blood pressure as the major risk factors for diabetic nephropathy in the Oji-Cree population.
|
17493550 |
2007 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The interaction of the PPARγ Pro12Ala polymorphism with diabetes and cardiovascular risk is controversial.
|
22017455 |
2012 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index.
|
17213274 |
2007 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk.
|
17563457 |
2007 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There appears to be certain genes which predispose Indians to diabetes while other genes (for example Pro 12 Ala polymorphism of PPAR gamma gene) which afford protection against diabetes and insulin resistance to Caucasians, do not appear to protect Indians.
|
17496355 |
2007 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes.
|
21877956 |
2012 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There were significant associations of the Pro12Ala single nucleotide polymorphism (SNP) genotypes with diabetes in both case-control comparisons (P=0.025 and P=0.039).
|
16401314 |
2005 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the Pro</span>12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We determined, by polymerase chain reaction (PCR), the Pro12Ala PPARgamma2 and the eNOS 4a/b gene polymorphisms in a total of 395 patients with diabetes mellitus 2 (DM2) (225 men and 170 women) from the LIANCO (Lipid-Analytic-Cologne) study.
|
15662218 |
2005 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the effect-modifying role of Pro12Ala on the 1 year change in obesity-related traits in a randomised clinical trial of treatment with metformin (n = 989), troglitazone (n = 363) or lifestyle modification (n = 1,004) vs placebo (n = 1,000) for diabetes prevention in high-risk individuals.
|
17898990 |
2007 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
When these 6 traits were included in a multivariate analysis, body mass index, systolic and diastolic blood pressures, triglyceride levels, and glucose concentration remained significantly associated with the P12A variant (P < 0.05), whereas the effect of P12A on liability for diabetes was not significant.
|
11158005 |
2001 |