rs4876369
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale.
|
30457165 |
2019 |
rs4968309
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C allele and CC genotype of rs4968309 and A allele of rs1515751were associated with AF onset both before and after adjustment of covariation (age, sex, hypertension, and diabetes).
|
31406021 |
2019 |
rs498005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> C allele of rs498005 was significantly correlated with increased risk of AF (OR = 1.412, 95%CI = 1.012-1.970), and the association still exited after adjustment by age, gender, the status of smoking and drinking, histories of diabetes, hyperlipidaemia and myocardial infarction (adjusted OR = 1.473, 95%CI = 1.043-2.081).
|
31315459 |
2019 |
rs531564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The meta-analysis indicated that the G allele or GG genotype of miR-146a rs2910164 was associated with a significantly increased risk for DM compared with C allele or GC/CC genotype in Latin American population; CC genotype of miR-27a rs895819 polymorphism was associated with a significantly decreased risk for DM in Asian population compared with the TT genotype; patients carrying with CC genotype of miR-124 rs531564 had a lower probability to develop DM regardless of ethnicity; no associations were identified between polymorphisms in miR-375, miR-128a, miR-194a and the susceptibility to DM.
|
31689753 |
2019 |
rs536289169
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C allele of C47T variant (SOD) was protective against DN, DR and microvascular complications of diabetes.
|
28548478 |
2019 |
rs550057
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetically instrumented blood lead was not associated with CAD (odds ratio (OR) 1.01 per effect size of log transformed blood lead, 95% confidence interval (CI) 0.97, 1.05), blood pressure (systolic -0.18 mmHg, 95% CI -0.44 to 0.08 and diastolic -0.03 mmHg, 95% CI -0.09 to 0.15) or diabetes (OR 0.98, 95% CI 0.92 to 1.03) using MR-PRESSO estimates corrected for an outlier SNP (rs550057) from the highly pleiotropic gene ABO.
|
31690775 |
2019 |
rs713041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 [27-42] years old; diabetes duration: 21 [15-27] years; HbA1c: 8.3% [7.4-9.4]; as median [interquartile interval]).
|
30599773 |
2019 |
rs74830677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the P376L variant were significantly more likely than non-carriers to develop CVD using multivariate analyses adjusted for traditional CVD risk factors defined as: age, sex, BMI, presence of diabetes, or hypertension, positive smoking habit, and total cholesterol (OR: 3.75, 95%CI: 1.76-7.98, p = 0.001).
|
31251897 |
2019 |
rs75418188
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five sequence variants in SLC16A11 (rs117767867, rs13342692, rs13342232, rs75418188, and rs75493593), which occur in two non-reference haplotypes, were recently shown to be associated with diabetes in Mexicans from the SIGMA consortium.
|
30696834 |
2019 |
rs78655421
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We present a non-consanguineous family of three siblings who presented with diabetes mellitus (DM), two of whom had genetically confirmed cystic fibrosis (CF), with one pancreatic-sufficient mutation in the cystic fibrosis transmembrane conductance regulator (<i>CFTR</i>) gene (ΔF508/R117H;IVS8-5T).
|
30269055 |
2019 |
rs7936247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Compared with women with a family history of diabetes, there was a significant association of rs7936247 with GDM risk among pregnant women without a family history of diabetes (OR 1.20; 95% CI 1.04-1.38; P = 0.014; P<sub>heterogeneity</sub> = 0.035).
|
30912250 |
2019 |
rs8192675
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C variant allele of rs8192675 was associated with a higher prevalence of diabetes symptoms at diabetes diagnosis.
|
30413829 |
2019 |
rs867120336
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutation screening for 30 diabetes-associated genes identified a heterozygous KLF11 variant (p.His418Gln) in the proband and his sister.
|
31124255 |
2019 |
rs892066
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between rs2278426 (C/T) and rs892066 (C/G) variants of ANGPTL8 (betatrophin) and susceptibility to type2 diabetes mellitus.
|
30191588 |
2019 |
rs905283251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a previously reported p.Arg377Ter variant of RFX6 in a three-generation family with diabetes.
|
31001871 |
2019 |
rs9282541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCA1 R230C T allele gene mutation is a protective in decreasing the risk of diabetes in Caucasians and ABCA1 C69T gene mutation markedly influences the level of lipid metabolism in diabetic patients.
|
31010439 |
2019 |
rs9470794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations were found between diabetes risk and SNPs in the MTNR1B (rs10830963), KLHDC5 (rs10842994), GRK5 (rs10886471), cyclindependentkinase 5 regulatory subunit associated protein 1 (rs10946398), adaptorrelated protein complex 3 subunit sigma 2 (rs2028299), diacylglycerol kinase beta/transmembrane protein 195 (rs2191349), SREBF chaperone (rs4858889), ankyrin1 (rs516946), RAS guanyl releasing protein 1 (rs7403531), and zinc finger AN1-type containing 3 (rs9470794) genes.
|
30907055 |
2019 |
rs9926289
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
rs10116772
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in strong correlation with rs10116772 have been associated with elevated plasma glucose levels and diabetes.
|
29436472 |
2018 |
rs1050828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recently published example is the erythrocytic variant (rs1050828) in G6PD, which leads to the artificial lowering of HbA1c and missed diagnosis of diabetes using current thresholds.
|
29522974 |
2018 |
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the general population, genetic variants affecting vitamin D metabolism (<i>DHCR7</i> rs12785878, <i>CYP2R1</i> rs10741657, <i>GC</i> rs4588) have been associated with serum vitamin D. We studied the association of these variants with serum vitamin D in 2163 patients with T2D from the "Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes".
|
30405883 |
2018 |
rs10757283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Islets from donors without diabetes (<i>n</i> = 95) were tested for SNP genotype (rs10811661, rs2383208, rs564398, and rs10757283), gene expression (<i>p14</i>, <i>p15</i>, <i>p16</i>, <i>MTAP</i>, <i>ANRIL</i>, <i>PCNA</i>, <i>KI67</i>, and <i>CCND2</i>), insulin secretion (<i>n</i> = 61), and β-cell proliferation (<i>n</i> = 47).
|
29432124 |
2018 |
rs1260236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among whites, rs34459162, a novel missense single nucleotide polymorphism (SNP) in <i>RCN3</i>, was associated with fructosamine (<i>P</i> = 5.3 × 10<sup>-9</sup>) and rs1260236, a known diabetes-related missense mutation in <i>GCKR</i>, was associated with percent glycated albumin (<i>P</i> = 5.9 × 10<sup>-9</sup>) and replicated in CARDIA.
|
29844224 |
2018 |
rs12785878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the general population, genetic variants affecting vitamin D metabolism (<i>DHCR7</i> rs12785878, <i>CYP2R1</i> rs10741657, <i>GC</i> rs4588) have been associated with serum vitamin D. We studied the association of these variants with serum vitamin D in 2163 patients with T2D from the "Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes".
|
30405883 |
2018 |
rs1308346790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A c.839C>T (p.(Thr280Met)) variant (rs200998587:C>T, risk allele frequency = 0.03) in RBPJL, identified only in Amerindian-derived populations, associated with T2D (OR = 1.60[1.21-2.13] per Met allele, P = 0.001) and age of diabetes onset (HR = 1.40[1.14-1.72], P = 0.001).
|
29302047 |
2018 |