Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4876369
rs4876369
0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165

2019

dbSNP: rs4968309
rs4968309
0.010 GeneticVariation BEFREE C allele and CC genotype of rs4968309 and A allele of rs1515751were associated with AF onset both before and after adjustment of covariation (age, sex, hypertension, and diabetes). 31406021

2019

dbSNP: rs498005
rs498005
0.010 GeneticVariation BEFREE <b>Results:</b> C allele of rs498005 was significantly correlated with increased risk of AF (OR = 1.412, 95%CI = 1.012-1.970), and the association still exited after adjustment by age, gender, the status of smoking and drinking, histories of diabetes, hyperlipidaemia and myocardial infarction (adjusted OR = 1.473, 95%CI = 1.043-2.081). 31315459

2019

dbSNP: rs531564
rs531564
0.010 GeneticVariation BEFREE The meta-analysis indicated that the G allele or GG genotype of miR-146a rs2910164 was associated with a significantly increased risk for DM compared with C allele or GC/CC genotype in Latin American population; CC genotype of miR-27a rs895819 polymorphism was associated with a significantly decreased risk for DM in Asian population compared with the TT genotype; patients carrying with CC genotype of miR-124 rs531564 had a lower probability to develop DM regardless of ethnicity; no associations were identified between polymorphisms in miR-375, miR-128a, miR-194a and the susceptibility to DM. 31689753

2019

dbSNP: rs536289169
rs536289169
0.010 GeneticVariation BEFREE C allele of C47T variant (SOD) was protective against DN, DR and microvascular complications of diabetes. 28548478

2019

dbSNP: rs550057
rs550057
ABO
0.010 GeneticVariation BEFREE Genetically instrumented blood lead was not associated with CAD (odds ratio (OR) 1.01 per effect size of log transformed blood lead, 95% confidence interval (CI) 0.97, 1.05), blood pressure (systolic -0.18 mmHg, 95% CI -0.44 to 0.08 and diastolic -0.03 mmHg, 95% CI -0.09 to 0.15) or diabetes (OR 0.98, 95% CI 0.92 to 1.03) using MR-PRESSO estimates corrected for an outlier SNP (rs550057) from the highly pleiotropic gene ABO. 31690775

2019

dbSNP: rs713041
rs713041
0.010 GeneticVariation BEFREE Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 [27-42] years old; diabetes duration: 21 [15-27] years; HbA1c: 8.3% [7.4-9.4]; as median [interquartile interval]). 30599773

2019

dbSNP: rs74830677
rs74830677
0.010 GeneticVariation BEFREE Carriers of the P376L variant were significantly more likely than non-carriers to develop CVD using multivariate analyses adjusted for traditional CVD risk factors defined as: age, sex, BMI, presence of diabetes, or hypertension, positive smoking habit, and total cholesterol (OR: 3.75, 95%CI: 1.76-7.98, p = 0.001). 31251897

2019

dbSNP: rs75418188
rs75418188
0.010 GeneticVariation BEFREE Five sequence variants in SLC16A11 (rs117767867, rs13342692, rs13342232, rs75418188, and rs75493593), which occur in two non-reference haplotypes, were recently shown to be associated with diabetes in Mexicans from the SIGMA consortium. 30696834

2019

dbSNP: rs78655421
rs78655421
0.010 GeneticVariation BEFREE We present a non-consanguineous family of three siblings who presented with diabetes mellitus (DM), two of whom had genetically confirmed cystic fibrosis (CF), with one pancreatic-sufficient mutation in the cystic fibrosis transmembrane conductance regulator (<i>CFTR</i>) gene (ΔF508/R117H;IVS8-5T). 30269055

2019

dbSNP: rs7936247
rs7936247
0.010 GeneticVariation BEFREE Compared with women with a family history of diabetes, there was a significant association of rs7936247 with GDM risk among pregnant women without a family history of diabetes (OR 1.20; 95% CI 1.04-1.38; P = 0.014; P<sub>heterogeneity</sub>  = 0.035). 30912250

2019

dbSNP: rs8192675
rs8192675
0.010 GeneticVariation BEFREE The C variant allele of rs8192675 was associated with a higher prevalence of diabetes symptoms at diabetes diagnosis. 30413829

2019

dbSNP: rs867120336
rs867120336
0.010 GeneticVariation BEFREE Mutation screening for 30 diabetes-associated genes identified a heterozygous KLF11 variant (p.His418Gln) in the proband and his sister. 31124255

2019

dbSNP: rs892066
rs892066
0.010 GeneticVariation BEFREE Association between rs2278426 (C/T) and rs892066 (C/G) variants of ANGPTL8 (betatrophin) and susceptibility to type2 diabetes mellitus. 30191588

2019

dbSNP: rs905283251
rs905283251
0.010 GeneticVariation BEFREE We identified a previously reported p.Arg377Ter variant of RFX6 in a three-generation family with diabetes. 31001871

2019

dbSNP: rs9282541
rs9282541
0.010 GeneticVariation BEFREE ABCA1 R230C T allele gene mutation is a protective in decreasing the risk of diabetes in Caucasians and ABCA1 C69T gene mutation markedly influences the level of lipid metabolism in diabetic patients. 31010439

2019

dbSNP: rs9470794
rs9470794
0.010 GeneticVariation BEFREE Associations were found between diabetes risk and SNPs in the MTNR1B (rs10830963), KLHDC5 (rs10842994), GRK5 (rs10886471), cyclindependentkinase 5 regulatory subunit associated protein 1 (rs10946398), adaptorrelated protein complex 3 subunit sigma 2 (rs2028299), diacylglycerol kinase beta/transmembrane protein 195 (rs2191349), SREBF chaperone (rs4858889), ankyrin1 (rs516946), RAS guanyl releasing protein 1 (rs7403531), and zinc finger AN1-type containing 3 (rs9470794) genes. 30907055

2019

dbSNP: rs9926289
rs9926289
FTO
0.010 GeneticVariation BEFREE Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192). 31823921

2019

dbSNP: rs10116772
rs10116772
0.010 GeneticVariation BEFREE Variants in strong correlation with rs10116772 have been associated with elevated plasma glucose levels and diabetes. 29436472

2018

dbSNP: rs1050828
rs1050828
0.010 GeneticVariation BEFREE A recently published example is the erythrocytic variant (rs1050828) in G6PD, which leads to the artificial lowering of HbA1c and missed diagnosis of diabetes using current thresholds. 29522974

2018

dbSNP: rs10741657
rs10741657
0.010 GeneticVariation BEFREE In the general population, genetic variants affecting vitamin D metabolism (<i>DHCR7</i> rs12785878, <i>CYP2R1</i> rs10741657, <i>GC</i> rs4588) have been associated with serum vitamin D. We studied the association of these variants with serum vitamin D in 2163 patients with T2D from the "Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes". 30405883

2018

dbSNP: rs10757283
rs10757283
0.010 GeneticVariation BEFREE Islets from donors without diabetes (<i>n</i> = 95) were tested for SNP genotype (rs10811661, rs2383208, rs564398, and rs10757283), gene expression (<i>p14</i>, <i>p15</i>, <i>p16</i>, <i>MTAP</i>, <i>ANRIL</i>, <i>PCNA</i>, <i>KI67</i>, and <i>CCND2</i>), insulin secretion (<i>n</i> = 61), and β-cell proliferation (<i>n</i> = 47). 29432124

2018

dbSNP: rs1260236
rs1260236
0.010 GeneticVariation BEFREE Among whites, rs34459162, a novel missense single nucleotide polymorphism (SNP) in <i>RCN3</i>, was associated with fructosamine (<i>P</i> = 5.3 × 10<sup>-9</sup>) and rs1260236, a known diabetes-related missense mutation in <i>GCKR</i>, was associated with percent glycated albumin (<i>P</i> = 5.9 × 10<sup>-9</sup>) and replicated in CARDIA. 29844224

2018

dbSNP: rs12785878
rs12785878
0.010 GeneticVariation BEFREE In the general population, genetic variants affecting vitamin D metabolism (<i>DHCR7</i> rs12785878, <i>CYP2R1</i> rs10741657, <i>GC</i> rs4588) have been associated with serum vitamin D. We studied the association of these variants with serum vitamin D in 2163 patients with T2D from the "Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes". 30405883

2018

dbSNP: rs1308346790
rs1308346790
0.010 GeneticVariation BEFREE A c.839C>T (p.(Thr280Met)) variant (rs200998587:C>T, risk allele frequency = 0.03) in RBPJL, identified only in Amerindian-derived populations, associated with T2D (OR = 1.60[1.21-2.13] per Met allele, P = 0.001) and age of diabetes onset (HR = 1.40[1.14-1.72], P = 0.001). 29302047

2018