rs3957146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest associations in the MHC class II region (rs3957146, β [SE] = 1.44 [0.05]), as well as the independent effect of MHC class I genes, on type 1 diabetes risk, particularly <i>HLA-B*39</i> (β [SE] = 1.36 [0.17]), were confirmed.
|
31843946 |
2020 |
rs5400
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]).
|
31728565 |
2020 |
rs10766196
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP2R1 rs12794714 and rs10766196 polymorphisms were associated with a higher risk of type 1 diabetes.
|
31206955 |
2019 |
rs10914542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study reveals that the G allele of SNP rs10914542 of LCK impairs the TCR/CD3-mediated T-cell activation and increases the risk of T1D.
|
31112992 |
2019 |
rs11014284
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evidence of association between variants in <i>CACNB2</i> and PDR was also found in association analysis of 4,005 individuals with type 1 diabetes with an odds ratio of 0.83 and <i>P</i> value of 8.6 × 10<sup>-4</sup> for rs11014284.
|
31439644 |
2019 |
rs11568820
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher cord blood 25(OH)D levels were associated with lower T1D risk (OR = 0.87 [95% CI 0.77-0.98] per 10 nmol/L increase) in children carrying the <i>VDR</i> rs11568820 G/G genotype (<i>P</i><sub>interaction</sub> = 0.01 between 25(OH)D level and rs11568820).
|
30692241 |
2019 |
rs11614913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Power analysis of the data yielded a statistical power of 80% for the miR-196a2 rs11614913</span> with T1DM.
|
31472066 |
2019 |
rs11651270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, the polymorphism rs11651270 was also related to T1D in an additive model (OR = 0.719, 95% CI = 0.583-0.887).
|
31396539 |
2019 |
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1800624 SNP involves <i>AGER</i> gene regulation and may be related to reduced risk of heart disease, cancer, Crohn's disease, and type 1 diabetes complications.
|
30863465 |
2019 |
rs2043211
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, we found no association of <i>NLRP3</i> rs35829419 and <i>CARD8</i> rs2043211 with the development of T1D, CD or both diseases together.
|
30915320 |
2019 |
rs2281135
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNP-diagnosis pairs passed the phenome-wide significance threshold: rs9273349 and E06 (thyroiditis, p = 5.50x10-8); rs9273349 and E10 (type-1 diabetes, p = 2.60x10-7); and rs2281135 and K76 (non-alcoholic liver diseases, including NAFLD, p = 4.10x10-7).
|
30978214 |
2019 |
rs2670660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs11651270 and rs2670660 polymorphisms were associated with T1D in the Chinese Han population under a dominant model (OR = 0.648, 95% CI = 0.503-0.834 and OR = 0.716, 95% CI = 0.549-0.934, respectively) and an overdominant model (OR = 0.663, 95% CI = 0.511-0.860 and OR = 0.711, 95% CI = 0.541-0.935, respectively).
|
31396539 |
2019 |
rs3176792
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identify four SNPs (rs10772119, rs10772120, rs3176792, rs883868) in linkage disequilibrium (LD) with T1D-associated GWAS lead SNPs that alter enhancer activity and expression of immune genes.
|
30910956 |
2019 |
rs35829419
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, we found no association of <i>NLRP3</i> rs35829419 and <i>CARD8</i> rs2043211 with the development of T1D, CD or both diseases together.
|
30915320 |
2019 |
rs45450798
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
rs5742909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further subgroup analyses revealed that rs231775 polymorphism was significantly associated with susceptibility to T1DM in Caucasians and South Asians, and rs5742909 polymorphism was significantly associated with susceptibility to T1DM in South Asians.
|
30988065 |
2019 |
rs883868
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identify four SNPs (rs10772119, rs10772120, rs3176792, rs883868) in linkage disequilibrium (LD) with T1D-associated GWAS lead SNPs that alter enhancer activity and expression of immune genes.
|
30910956 |
2019 |
rs9273349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNP-diagnosis pairs passed the phenome-wide significance threshold: rs9273349 and E06 (thyroiditis, p = 5.50x10-8); rs9273349 and E10 (type-1 diabetes, p = 2.60x10-7); and rs2281135 and K76 (non-alcoholic liver diseases, including NAFLD, p = 4.10x10-7).
|
30978214 |
2019 |
rs941758
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed protective associations between three variants in the CXCL4L1 promoter (rs872914/A, rs941757/G, and rs941758/A) and renal function in patients with type 1 diabetes.
|
30593538 |
2019 |
rs10011025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, the association between the common rs10011025 variant in the GLRA3 locus, and albuminuria, was confirmed in 1259 independent Finnish individuals with type 1 diabetes (p = 0.0013), and meta-analysis of all Finnish individuals yielded a genome-wide significant association.
|
30120300 |
2018 |
rs10186193
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs10186193 (at RNASEH1 gene) showed association with T1D (P = 0.005).
|
29204916 |
2018 |
rs1041740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further studies are necessary to assess the relationship between rs1041740 and T1D or DPN.
|
29924645 |
2018 |
rs1121980
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through clinical statistics analysis, the different genotypes of rs1121980 can present different disease severity of IDD.
|
30099472 |
2018 |
rs1131568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the association between TRAIL-1525G/A (rs1131568) polymorphism and the susceptibility of IDD was statistically significant under all genetic models.
|
29652777 |
2018 |
rs1131580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a significant association between TRAIL-1595C/T (rs1131580) polymorphism with increased IDD risk under each genetic model (allele model: OR = 1.77, 95% CI 1.47-2.13, P = 0.000; homozygote model: OR = 2.44, 95% CI 1.70-3.51, P = 0.000; dominant model: OR = 1.67, 95% CI 1.22-2.29, P = 0.002; recessive model: OR = 3.13, 95% CI 2.40-4.08, P = 0.000).
|
29652777 |
2018 |