Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3957146
rs3957146
0.010 GeneticVariation BEFREE The strongest associations in the MHC class II region (rs3957146, β [SE] = 1.44 [0.05]), as well as the independent effect of MHC class I genes, on type 1 diabetes risk, particularly <i>HLA-B*39</i> (β [SE] = 1.36 [0.17]), were confirmed. 31843946

2020

dbSNP: rs5400
rs5400
0.010 GeneticVariation BEFREE The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]). 31728565

2020

dbSNP: rs10766196
rs10766196
0.010 GeneticVariation BEFREE CYP2R1 rs12794714 and rs10766196 polymorphisms were associated with a higher risk of type 1 diabetes. 31206955

2019

dbSNP: rs10914542
rs10914542
LCK
0.010 GeneticVariation BEFREE This study reveals that the G allele of SNP rs10914542 of LCK impairs the TCR/CD3-mediated T-cell activation and increases the risk of T1D. 31112992

2019

dbSNP: rs11014284
rs11014284
0.010 GeneticVariation BEFREE Evidence of association between variants in <i>CACNB2</i> and PDR was also found in association analysis of 4,005 individuals with type 1 diabetes with an odds ratio of 0.83 and <i>P</i> value of 8.6 × 10<sup>-4</sup> for rs11014284. 31439644

2019

dbSNP: rs11568820
rs11568820
VDR
0.010 GeneticVariation BEFREE Higher cord blood 25(OH)D levels were associated with lower T1D risk (OR = 0.87 [95% CI 0.77-0.98] per 10 nmol/L increase) in children carrying the <i>VDR</i> rs11568820 G/G genotype (<i>P</i><sub>interaction</sub> = 0.01 between 25(OH)D level and rs11568820). 30692241

2019

dbSNP: rs11614913
rs11614913
0.010 GeneticVariation BEFREE Power analysis of the data yielded a statistical power of 80% for the miR-196a2 rs11614913</span> with T1DM. 31472066

2019

dbSNP: rs11651270
rs11651270
0.010 GeneticVariation BEFREE Additionally, the polymorphism rs11651270 was also related to T1D in an additive model (OR = 0.719, 95% CI = 0.583-0.887). 31396539

2019

dbSNP: rs1800624
rs1800624
0.010 GeneticVariation BEFREE The rs1800624 SNP involves <i>AGER</i> gene regulation and may be related to reduced risk of heart disease, cancer, Crohn's disease, and type 1 diabetes complications. 30863465

2019

dbSNP: rs2043211
rs2043211
0.010 GeneticVariation BEFREE On the other hand, we found no association of <i>NLRP3</i> rs35829419 and <i>CARD8</i> rs2043211 with the development of T1D, CD or both diseases together. 30915320

2019

dbSNP: rs2281135
rs2281135
0.010 GeneticVariation BEFREE Three SNP-diagnosis pairs passed the phenome-wide significance threshold: rs9273349 and E06 (thyroiditis, p = 5.50x10-8); rs9273349 and E10 (type-1 diabetes, p = 2.60x10-7); and rs2281135 and K76 (non-alcoholic liver diseases, including NAFLD, p = 4.10x10-7). 30978214

2019

dbSNP: rs2670660
rs2670660
0.010 GeneticVariation BEFREE Both rs11651270 and rs2670660 polymorphisms were associated with T1D in the Chinese Han population under a dominant model (OR = 0.648, 95% CI = 0.503-0.834 and OR = 0.716, 95% CI = 0.549-0.934, respectively) and an overdominant model (OR = 0.663, 95% CI = 0.511-0.860 and OR = 0.711, 95% CI = 0.541-0.935, respectively). 31396539

2019

dbSNP: rs3176792
rs3176792
0.010 GeneticVariation BEFREE We identify four SNPs (rs10772119, rs10772120, rs3176792, rs883868) in linkage disequilibrium (LD) with T1D-associated GWAS lead SNPs that alter enhancer activity and expression of immune genes. 30910956

2019

dbSNP: rs35829419
rs35829419
0.010 GeneticVariation BEFREE On the other hand, we found no association of <i>NLRP3</i> rs35829419 and <i>CARD8</i> rs2043211 with the development of T1D, CD or both diseases together. 30915320

2019

dbSNP: rs45450798
rs45450798
0.010 GeneticVariation BEFREE Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies. 31808541

2019

dbSNP: rs5742909
rs5742909
0.010 GeneticVariation BEFREE Further subgroup analyses revealed that rs231775 polymorphism was significantly associated with susceptibility to T1DM in Caucasians and South Asians, and rs5742909 polymorphism was significantly associated with susceptibility to T1DM in South Asians. 30988065

2019

dbSNP: rs883868
rs883868
0.010 GeneticVariation BEFREE We identify four SNPs (rs10772119, rs10772120, rs3176792, rs883868) in linkage disequilibrium (LD) with T1D-associated GWAS lead SNPs that alter enhancer activity and expression of immune genes. 30910956

2019

dbSNP: rs9273349
rs9273349
0.010 GeneticVariation BEFREE Three SNP-diagnosis pairs passed the phenome-wide significance threshold: rs9273349 and E06 (thyroiditis, p = 5.50x10-8); rs9273349 and E10 (type-1 diabetes, p = 2.60x10-7); and rs2281135 and K76 (non-alcoholic liver diseases, including NAFLD, p = 4.10x10-7). 30978214

2019

dbSNP: rs941758
rs941758
0.010 GeneticVariation BEFREE We observed protective associations between three variants in the CXCL4L1 promoter (rs872914/A, rs941757/G, and rs941758/A) and renal function in patients with type 1 diabetes. 30593538

2019

dbSNP: rs10011025
rs10011025
0.010 GeneticVariation BEFREE In this study, the association between the common rs10011025 variant in the GLRA3 locus, and albuminuria, was confirmed in 1259 independent Finnish individuals with type 1 diabetes (p = 0.0013), and meta-analysis of all Finnish individuals yielded a genome-wide significant association. 30120300

2018

dbSNP: rs10186193
rs10186193
0.010 GeneticVariation BEFREE SNP rs10186193 (at RNASEH1 gene) showed association with T1D (P = 0.005). 29204916

2018

dbSNP: rs1041740
rs1041740
0.010 GeneticVariation BEFREE Further studies are necessary to assess the relationship between rs1041740 and T1D or DPN. 29924645

2018

dbSNP: rs1121980
rs1121980
FTO
0.010 GeneticVariation BEFREE Through clinical statistics analysis, the different genotypes of rs1121980 can present different disease severity of IDD. 30099472

2018

dbSNP: rs1131568
rs1131568
0.010 GeneticVariation BEFREE In addition, the association between TRAIL-1525G/A (rs1131568) polymorphism and the susceptibility of IDD was statistically significant under all genetic models. 29652777

2018

dbSNP: rs1131580
rs1131580
0.010 GeneticVariation BEFREE There was a significant association between TRAIL-1595C/T (rs1131580) polymorphism with increased IDD risk under each genetic model (allele model: OR = 1.77, 95% CI 1.47-2.13, P = 0.000; homozygote model: OR = 2.44, 95% CI 1.70-3.51, P = 0.000; dominant model: OR = 1.67, 95% CI 1.22-2.29, P = 0.002; recessive model: OR = 3.13, 95% CI 2.40-4.08, P = 0.000). 29652777

2018