rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Two of the 12 IL2RA SNPs genotyped (rs706778 and rs3118470) had statistically significant type 1 diabetes association (P = 6.96 x 10(-4) and 8.63 x 10(-4), respectively).
|
17395754 |
2007 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We found evidence of association with acute-onset, but not slow-onset and fulminant, type 1 diabetes for two of the four single-nucleotide polymorphisms genotyped (rs706778 and rs3118470).
|
19106270 |
2009 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We had previously shown rs3118470 to confer T1D susceptibility in a Canadian dataset, independently of rs41295061 as the major reported locus (p = 5 x 10(-3), after accounting for rs41295061 by conditional regression).
|
19794070 |
2009 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Previous investigations have also demonstrated that two intronic SNPs (rs706778 and rs3118470) in the interleukin-2 receptor-alpha (IL2RA) gene were associated with type 1 diabetes in the Japanese population.
|
20615141 |
2010 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In contrast, the minor C allele at rs3118470 appeared to be significantly associated with the occurrence of T1D (P = 0.003; OR = 1.30; 95% CI = 1.094-1.550).
|
22211793 |
2012 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Using minor allelic comparison, the five investigated SNPs were all observed to have a significant association with T1D: For rs11594656, fixed effect model (FEM) odds ratio (OR) 0.87, 95% confidence interval (CI) 0.83, 0.91; rs2104286, FEM OR 0.81, 95% CI 0.77, 0.85; rs3118470, FEM OR 1.23, 95% CI 1.16, 1.31; rs41295061, random effect model (REM) OR 0.67, 95% CI 0.60, 0.76 and rs706778 FEM OR 1.20, 95% CI 1.08, 1.33.
|
26249556 |
2015 |
rs3118470
|
|
|
0.070 |
GeneticVariation |
BEFREE |
However, stratification by IL2RA single-nucleotide polymorphisms revealed that T1D subjects with the rs3118470 CC risk variant have Tregs with IL-2 signaling defects and an increased proportion of FOXP3<sup>+</sup>IL-17<sup>+</sup> cells before diagnosis.
|
28053319 |
2017 |