Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE The IFIH1 rs1990760 polymorphism seems to be associated with the seasonal manifestation of T1DM. 28929635

2018

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE In summary, our study uncovers an influence of rs1990760 on the canonical effector function of MDA5 in response to an acute infection of primary human parenchymal cells with a clinically relevant virus linked to human T1D. 28000722

2016

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE The risk alleles G of rs3747517, rs2111485, rs13422767 and A of rs1990760 were observed more frequently in T1D group with P values and allelic odds ratio OR (95%CI) < 0.0001, 1.742 (1.428-2.126); 0.001, 1.336 (1.125-1.588); < 0.0001, 1.799 (1.416-2.285); 0.0005, 1.359 (1.144-1.616), respectively. 25515714

2015

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE Additionally, we conducted a meta-analysis with the rs7574865 SNP in STAT4 (1392 T1D patients and 1629 controls) and the rs1990760 SNP in IFIH1 (25092 T1D patients and 28544 controls) to examine their association with T1D. 26782418

2015

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus. 24117221

2014

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE This meta-analysis demonstrates that the IFIH1 rs1990760 T-allele confers susceptibility to T1D, SLE, MS and RA and suggests that the IFIH1 rs1990760 polymorphism might have no effect on GD and AAD. 23734776

2013

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE Interestingly, the rs1990760 A allele seems to be associated with protection for AH in T1DM patients. 24386202

2013

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population. 22053898

2012

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1. 23144876

2012

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation GWASDB A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. 21980299

2011

dbSNP: rs1990760
rs1990760
C 0.900 GeneticVariation GWASCAT Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. 21829393

2011

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE Summarising the data published so far, a clear association between the Ala946Thr polymorphism and type 1 diabetes was detected, with an apparent difference in the contribution to disease susceptibility in different populations of European ancestry. 19841890

2010

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE In addition to the known association of HLA with IgAD, we identified association with a nonsynonymous variant in IFIH1 (rs1990760G>A, P = 7.3 x 10(-10)) which was previously associated with type 1 diabetes and systemic lupus erythematosus. 20694011

2010

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE Moreover, the association of the Thr946Ala SNP with T1D is not due to modulation of IFIH1 expression in organs involved in the disease, pointing to the IFIH1 nsSNP as the causal variant. 20644636

2010

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation GWASDB Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480

2009

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE Among the 10 SNPs genotyped for the 2q region, four SNPs located within the IFIH1 gene or at the 5' region of IFIH1 showed significant association with T1D in the Georgia population [odds ratio (OR) = 1.7-1.9] with the best P-value found at SNP rs1990760 (P = 8 x 10(-8) and OR = 1.9). 18927125

2009

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD). 19961590

2009

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation GWASCAT Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480

2009

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE However, the A946T mutation of MDA5, which has been implicated in type I diabetes by previous genetic analyses, affected neither dsRNA binding nor IFN gene activation. 19324880

2009

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE Evidence for association with T1D was observed for the IFIH1 SNP, rs1990760 (P=7.0 x 10(-4)), with RR=0.88 (0.82-0.95) and the CTLA4 SNP rs1427676 (P=0.0005), with RR=1.14 (1.06-1.23). 19956106

2009

dbSNP: rs1990760
rs1990760
A 0.900 GeneticVariation GWASCAT Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. 17554260

2007

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE A recent large-scale analysis of nonsynonymous coding polymorphisms showed strong evidence that an alanine to threonine amino acid change at codon 946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was associated with type 1 diabetes. 17535987

2007

dbSNP: rs1990760
rs1990760
0.900 GeneticVariation BEFREE The aim of the present study was to investigate the role of the interferon induced with helicase domain 1 (IFIH1) A946T (rs1990760 A>G) variant in rheumatoid arthritis (RA), as this was recently associated with susceptibility to type 1 diabetes. 17442111

2007

dbSNP: rs1990760
rs1990760
A 0.900 GeneticVariation GWASDB Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. 17554260

2007