|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.
|
22884980 |
2012 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study demonstrates significant associations of SUMO4 M55V polymorphism with T1DM in Asian and Caucasian population and with T2DM in Asian population.
|
22936652 |
2012 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M55V substitution of SUMO4 may affect its ability to modify IκBα by sumoylation, and so lead to activation of NFκB and transcription of genes implicated in the development of type 1 diabetes.
|
22423385 |
2012 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a novel gene encoding small ubiquitin-like modifier protein 4 (SUMO4) was cloned and a single nucleotide substitution (M55V) was found to be strongly associated with type 1 diabetes.
|
22069273 |
2011 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of SUMO4 M55V polymorphism with type 1 diabetes in Chinese children.
|
21158221 |
2010 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Met55Val polymorphism in the small ubiquitin-like modifier 4 (SUMO4) gene has been associated with susceptibility not only to type 1 diabetes, but also to type 2 diabetes and diabetic nephropathy.
|
19410319 |
2009 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data indicate that the M55V polymorphism in the SUMO4 gene is associated with a reduced risk of diabetic retinopathy in type 1 diabetes.
|
17926234 |
2008 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent reports demonstrated that a polymorphism with an amino acid substitution (Met55Val) in SUMO4 was associated with type 1 diabetes in Asian populations, although no association was reproduced in subjects of Caucasian descent.
|
17374705 |
2007 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on IDDM5 have led to the discovery of a novel polymorphism 163 A-->G (M55V) in SUMO4 gene, which was found to be associated with T1D patients with Asian origin.
|
17448564 |
2007 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Asian-Indians show more similarity to Caucasians with respect to the association of SUMO4 M55V variant in T1DM.
|
17373940 |
2007 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
From the current study, we conclude that SUMO4 M55V is associated with TIDM</span> in association with high-risk HLA-DR3 and DR4, but not by itself.
|
17554341 |
2007 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no significant association between SUMO4 M55V</span> and T1DM susceptibility in Latvians, the results being in concurrence with the previous studies in Caucasians of British and Canadian origin.
|
17130565 |
2006 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M55V variant of SUMO4 was significantly associated with type 1 diabetes in Asians, but genetic heterogeneity between Asian and Caucasian populations was suggested.
|
17130532 |
2006 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the association of SUMO4 M55V variant was stronger in type 1 diabetic patients complicated with AITD (OR, 1.62; 95% CI, 1.06-2.47; P = 0.023) and in patients who have neither type 1 diabetes-susceptible class II HLA, DRB1*0405 nor DRB1*0901 (OR, 2.28; 95% CI, 1.34-3.87; P = 0.0018).
|
16735488 |
2006 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent study demonstrated that M55V variant in SUMO4 at IDDM5 was associated with susceptibility to type 1 diabetes.
|
17130530 |
2006 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M55V polymorphism was significantly associated with type 1 diabetes in Asian populations (summary odds ratio [OR] 1.46, P = 0.00083, Mantel-Haenszel test).
|
16306380 |
2005 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SUMO4 codon 55 methionine to valine polymorphism may be exclusively associated with susceptibility to T1D, or the effect of the locus in GD and Addison's disease may be much less than that found in T1D patients.
|
15730420 |
2005 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An association of a methionine-to-valine polymorphism (rs237025, 163A --> G, M55V) in the SUMO4 gene within IDDM5 has recently been described in T1D.
|
16159953 |
2005 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A substitution (M55V) at an evolutionarily conserved residue of the crucial CUE domain of SUMO4 was strongly associated with T1D (P = 1.9 x 10(-7)).
|
15247916 |
2004 |
|
rs237025
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.
|
15123604 |
2004 |