|
rs11558471
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We conclude that type 2 diabetes is associated with the AA genotype of rs11558471 in the human SLC30A8 gene.
|
22653633 |
2012 |
|
rs11558471
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied.
|
20550665 |
2010 |
|
rs11558471
|
|
|
0.720 |
GeneticVariation |
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs13266634
|
|
C |
1.000 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs13266634
|
|
C |
1.000 |
GeneticVariation |
GWASCAT |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index.
|
20509872 |
2010 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We replicated the association with type 2 diabetes for rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p=0.004), rs9939609 in FTO (OR 1.14, 95% CI: 1.04-1.25, p=0.006) and rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p=3.9 x 10(-4)).
|
18437351 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A significant association with type 2 diabetes was not observed for rs13266634.
|
17971426 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The variant rs13266634 in SLC30A8, encoding a β-cell-specific zinc transporter, is associated with type 2 diabetes.
|
24471563 |
2014 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We estimate that the rs13266634 single nucleotide polymorphism, a type 2 diabetes susceptibility genotype, has a genetic prevalence of 56.3%, 47.4% and 37.0% in Mexican Mestizo, Caucasian, and Asian populations.
|
25875676 |
2015 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our results suggest that rs13266634 may be an important genetic factor of type 2 diabetes risk among Asian and European but not African populations.
|
26214053 |
2015 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our study suggested that the C allele of rs13266634 was associated with higher odds of T2D, and higher plasma zinc was associated with lower odds.
|
24306209 |
2014 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The R325W C-allele were more frequent in women with GDM compared to in controls (OR 1.47, 95 % CI 1.16-1.88, p = 0.0018) but not significantly increased in women with GDM and postpartum development of type 2 diabetes.
|
27003436 |
2016 |
|
rs13266634
|
|
C |
1.000 |
GeneticVariation |
GWASCAT |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The solute carrier family 30 member 8 gene (<i>SLC30A8</i>) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in <i>SLC30A8</i> is associated with an increased risk of type 2 diabetes (T2D).
|
29093761 |
2017 |
|
rs13266634
|
|
C |
1.000 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
SLC30A8 rs13266634 risk C allele frequency was higher in T2DM patients than in healthy controls (P < 0.05).
|
20809084 |
2010 |
|
rs13266634
|
|
C |
1.000 |
GeneticVariation |
GWASCAT |
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
|
19734900 |
2009 |
|
rs13266634
|
|
T |
1.000 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
ZnT8 null mice have a mild phenotype with a slight decrease in glucose tolerance, whereas patients with the ZnT8 R325W polymorphism (rs13266634) have decreased proinsulin staining and susceptibility to T2DM.
|
27899481 |
2017 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> The present meta-analysis demonstrated that <i>SLC30A8</i> rs13266634 was a potential risk factor for T2DM, and more studies should be performed to confirm the association between rs13266634 polymorphism and IGR.
|
30319545 |
2018 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
GWASDB |
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
|
21874001 |
2011 |
|
rs13266634
|
|
C |
1.000 |
GeneticVariation |
GWASCAT |
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
|
26818947 |
2016 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
SLC30A8 encodes a zinc transporter in the beta cell; individuals with a common missense variant (rs13266634; R325W) in SLC30A8 demonstrate a lower early insulin response to glucose and an increased risk of type 2 diabetes.
|
25348609 |
2015 |