rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The provariant of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)gamma has been identified as a risk allele for type 2 diabetes.
|
17065690 |
2006 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism and its reported relationship to type 2 diabetes susceptibility and body mass accumulation prompted us to investigate the impact of this single nucleotide polymorphism (SNP) on antipsychotic-induced changes of body weight and body mass index (BMI) in a naturalistic study design.
|
22413765 |
2012 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The PPARgamma Pro12Ala polymorphism has been associated in several studies with a decreased risk of obesity, type 2 diabetes and insulin resistance.
|
17408525 |
2007 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These variants may contribute significantly to the risk type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys).
|
15715885 |
2005 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a Mendelian randomization design, both HOMA-IR (instrumental variables: rs1801282, rs4607103) and βF (instrumental variable: rs4607103) were related to T2DM (p < 0.03-0.01 and p < 0.03, respectively).
|
23161442 |
2013 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three-site haplotype analysis in the PPARG locus using the 2 marginally associated SNPs (P/rs11715073 and P/rs3892175) in combination with Pro12 Ala (P/rs1801282) revealed a strong association of 1 "risk" (CGC) (P = .003, permutation P = .015) and 1 "protective" (CAC) (P = .001, permutation P = .005) haplotype associated with T2D.
|
19846176 |
2010 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our aim was to study the interaction effect between PPARγ gene (PPARG) polymorphisms Pro12Ala and 1431C>T and fat intake on incident T2D and BMI in a 9-year prospective cohort drawn from the French general population, the D.E.S.I.R.
|
21540831 |
2012 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Polymorphism of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala in the Iranian population: relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes.
|
21968139 |
2011 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Hence, our aim was to develop a low-cost method for the validation of PPARG (Pro12Ala, CCA>GCA) SNP (rs1801282) for its association with T2D.
|
25063576 |
2014 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although our data indicate that the PPARG2 gene variants, independently, have no association with type 2 diabetes mellitus, the 2-loci genotype analysis involving -1279G/A and Pro12Ala variants and the 3-loci haplotype analysis have shown a significant association with type 2 diabetes mellitus in this South Indian population.
|
19846173 |
2010 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Pro12Ala mutation decreases PPARG activity and resistance to NIDDM.
|
22937051 |
2012 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D.
|
30064293 |
2018 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism (rs1801282), a nonsynonymous substitution of peroxisome proliferator-activated receptor-gamma (PPARG), has been robustly associated with type 2 diabetes.
|
19745552 |
2009 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results suggest that in the Taiwanese, the Pro12Ala PPARgamma2 gene variant may contribute to fat accumulation and a higher BMI independent of type 2 diabetes.
|
11079814 |
2000 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma 2 gene is suggested to associate with diabetic nephropathy and cardiovascular disease in type 2 diabetes.
|
18467141 |
2008 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
No effect of the Pro12Ala polymorphism on the rates of whole-body, skeletal muscle, or subcutaneous adipose tissue GU was observed in T2DM subjects.
|
19303976 |
2009 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among obese people, there was no association between any of the T2Dm or obesity-related traits and the Pro12Ala polymorphism.
|
16050954 |
2005 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Variation in PPARG, but not Pro12Ala, contributes to declining SI and concomitant deterioration in β-cell function in Mexican Americans at risk for T2DM.
|
25584717 |
2015 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The objective of the study was to test for an association between type 2 diabetes mellitus (T2DM) and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPAR-gamma) in families from Colorado.
|
17292728 |
2007 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Conflicting evidence exists as to whether the Pro12Ala single nucleotide polymorphism of the type 2 diabetes susceptibility gene peroxisome proliferator-activated receptor gamma (PPARG) also confers risk for type 1 diabetes (T1D).
|
18466209 |
2008 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The PPAR-gamma Pro12Ala gene polymorphism is associated with the response to pioglitazone in Chinese patients with type 2 diabetes mellitus.
|
20045142 |
2010 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis.
|
19766907 |
2009 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele.
|
23386649 |
2013 |
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Meanwhile PPARG-2 Pro12Ala, CDKN2A/2B rs10811661, IGF2BP2 rs4402960, HHEX rs7923837, CDKAL1 rs7754840, EXT2 rs1113132 and SLC30A8 rs13266634 were found to have no significant association with T2D among Arabs.
|
23458876 |
2013 |